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Physiological, neurochemical and morphological properties of a subgroup of GABAergic spinal lamina II neurones identified by expression of green fluorescent protein in mice
The processing of sensory, including nociceptive, information in spinal dorsal horn is critically modulated by spinal GABAergic neurones. For example, blockade of spinal GABAA receptors leads to painExpand
Synaptic Plasticity in Spinal Lamina I Projection Neurons That Mediate Hyperalgesia
Inflammation, trauma, or nerve injury may cause enduring hyperalgesia, an enhanced sensitivity to painful stimuli. Neurons in lamina I of the spinal dorsal horn that express the neurokinin 1 receptorExpand
Pre‐ and postsynaptic contributions of voltage‐dependent Ca2+ channels to nociceptive transmission in rat spinal lamina I neurons
Activation of voltage‐dependent Ca2+ channels (VDCCs) is critical for neurotransmitter release, neuronal excitability and postsynaptic Ca2+ signalling. Antagonists of VDCCs can be antinociceptive inExpand
Distinctive membrane and discharge properties of rat spinal lamina I projection neurones in vitro
Most lamina I neurones with a projection to the brainstem express the neurokinin 1 receptor and thus belong to a small subgroup of lamina I neurones that are necessary for the development ofExpand
Multiple Targets of μ-Opioid Receptor-Mediated Presynaptic Inhibition at Primary Afferent Aδ- and C-Fibers
Agonists at μ-opioid receptors (MORs) represent the gold standard for the treatment of severe pain. A key element of opioid analgesia is the depression of nociceptive information at the firstExpand
Physiological properties of spinal lamina II GABAergic neurons in mice following peripheral nerve injury
Aberrant GABAergic inhibition in spinal dorsal horn may underlie some forms of neuropathic pain. Potential, but yet unexplored, mechanisms include reduced excitability, abnormal discharge patterns orExpand
Synaptic mechanisms of hyperalgesia.
Publisher Summary Hyperalgesia and allodynia often aggravate pain for variable periods after trauma, surgery, and inflammation. Pain that is induced by normally nonpainful stimuli (allodynia) orExpand
Reduction of glycine receptor-mediated miniature inhibitory postsynaptic currents in rat spinal lamina I neurons after peripheral inflammation
Peripheral inflammation may induce long-lasting sensitization in the central nociceptive system. Neurons in lamina I of the spinal dorsal horn play a pivotal role in the integration and relay ofExpand
Impaired Excitatory Drive to Spinal Gabaergic Neurons of Neuropathic Mice
Adequate pain sensitivity requires a delicate balance between excitation and inhibition in the dorsal horn of the spinal cord. This balance is severely impaired in neuropathy leading to enhanced painExpand
Heterosynaptic Long-Term Potentiation at GABAergic Synapses of Spinal Lamina I Neurons
Neurons in spinal dorsal horn lamina I play a pivotal role for nociception that critically depends on a proper balance between excitatory and inhibitory inputs. Any modification in synaptic strengthExpand