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Prevention of autoimmune diabetes in NOD mice by troglitazone is associated with modulation of ICAM-1 expression on pancreatic islet cells and IFN-gamma expression in splenic T cells.
- P. Augstein, A. Dunger, +4 authors E. Salzsieder
- Biochemical and biophysical research…
- 2 May 2003
Thiazolidinediones acting as PPAR-gamma agonists are a new generation of oral antidiabetics addressing insulin resistance as a main feature of type-2 diabetes. In accordance to our results,… Expand
Autoimmune response directed to pancreatic beta cells in rats induced by combined treatment with low doses of streptozotocin and complete Freund's adjuvant.
- M. Ziegler, B. Ziegler, B. Hehmke, H. Dietz, W. Hildmann, C. Kauert
- Biomedica biochimica acta
Despite the existence of circumstantial evidence, a direct proof of an autoimmune basis for beta cell destruction in human type I diabetes has not yet been obtained. The present study was designed to… Expand
Antibody response to islet antigens in anti-CD4/prednisolone immune intervention of type 1 diabetes
- K. Kohnert, B. Hehmke, +4 authors D. Michaelis
- International journal of clinical & laboratory…
Cytoplasmic islet cell antibodies, glutamic acid decarboxylase autoantibodies, spontaneous insulin autoantibodies, and insulin-induced antibodies were analyzed in a 1-year follow-up study of 12 newly… Expand
Detection of antibodies to islet cell and splenic lymphocytes in diabetes-prone BB and adjuvant-streptozotocin treated Lewis rats by ELISA and immunoblot analysis.
An enzyme-linked immunosorbent assay (ELISA) has been developed to detect antibodies against surface components of rat islet and spleen lymphocytes. Live islet tumor RIN5 AH cells expressing… Expand
Severe hyperglycaemia caused by autoimmunization to beta cells in rats.
The non-specific activation of the immune system by administration of complete Freund's adjuvant was examined in Wistar rats as a possible means of amplification of the specific immune response… Expand
The use of a new dextran gradient medium for rapid isolation of functionally intact neonatal rat pancreatic islets.
The use of a new density gradient medium, Dextran M 70, is described for isolation of islets of Langerhans from collagenase digested pancreases of neonatal Wistar rats. Centrifugation in continuous… Expand
Preparation of suspensions of pancreatic islet cells: a comparison of methods.
A comparative study for preparation of cell suspensions from pancreatic islets has been performed using mechanical or enzymatic dissociation with proteolytic enzymes such as trypsin, dispase, and… Expand
Cytotoxic islet cell autoantibodies in newly diagnosed insulin-dependent diabetes mellitus: lack of correlation to age, residual beta cell function, HLA antigens and Coxsackie B virus antibodies.
- B. Hehmke, D. Michaelis, W. Hildmann, K. Richter, K. Kohnert
- Diabetes research
- 1 February 1987
In a cross-sectional study comprising of 56 patients with newly diagnosed insulin-dependent diabetes mellitus (IDDM) serum was examined for the presence of complement-dependent antibody mediated… Expand
Immunoadsorption of immunoglobulins alters intracytoplasmic type 1 and type 2 T cell cytokine production in patients with refractory autoimmune diseases.
- B. Hehmke, E. Salzsieder, G. Matic, R. Winkler, M. Tiess, W. Ramlow
- Therapeutic apheresis : official journal of the…
- 1 August 2000
Intracellular cytokine staining and flow cytometry were used to investigate whether immunoadsorption (IA) of immunoglobulins alters intracytoplasmic cytokine production in CD4+ and CD8+ T cells from… Expand
Effects of islet cell surface antibodies on isolated neonatal rat islets of Langerhans in vitro.
Islet cell surface antibodies (ICSA) were raised by immunization of rabbits with viable neonatal rat pancreatic islet cell suspensions. By absorption with liver powder and spleen cells unspecific… Expand