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THE MODE OF ACTION AT THE MOUSE NEUROMUSCULAR JUNCTION OF THE PHOSPHOLIPASE A‐CROTAPOTIN COMPLEX ISOLATED FROM VENOM OF THE SOUTH AMERICAN RATTLESNAKE
1 Phospholipase A2‐crotapotin complex (P‐C complex) isolated from the venom of Crotalus durissus terrificus induced an irreversible blockade of neuromuscular transmission when twitch tension wasExpand
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Pioneers of anti-venomous serotherapy: Dr Vital Brazil (1865-1950).
  • B. Hawgood
  • Medicine
  • Toxicon : official journal of the International…
  • 1 May 1992
Dr Vital Brazil was a great humanitarian and pioneer of medical science. His main work arose from his concern with poisonous snakebite accidents to labourers working the land. Vital Brazil estimatedExpand
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Poul Agerholm Christensen MD (1912-1991): antivenom production at the South African Institute for Medical Research.
  • B. Hawgood
  • Medicine
  • Toxicon : official journal of the International…
  • 1 June 2001
Dr Christensen arrived in Cape Town in June 1940 as ship's surgeon on a Danish cargo-liner. Denmark was under German control, and the ship came under command of the South African government for useExpand
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Cellular and mitochondrial changes induced in the structure of murine skeletal muscle by crotoxin, a neurotoxic phospholipase A2 complex.
Following a single i.m. injection of a sublethal dose of crotoxin into the hindlimb of mice, degenerative changes were observed in the soleus muscle in the ensuing 72 hr using light and electronExpand
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Morphological changes induced by crotoxin in murine nerve and neuromuscular junction.
The sequence and timing of structural changes induced by crotoxin were examined by electron microscopy following either a single systemic injection of a lethal dose or a single i.m. injection of aExpand
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Doctor Albert Calmette 1863-1933: founder of antivenomous serotherapy and of antituberculous BCG vaccination.
  • B. Hawgood
  • Medicine
  • Toxicon : official journal of the International…
  • 1 September 1999
In 1891 in Saigon (now Ho Chi Minh City), Dr. Albert Calmette established the first daughter Pasteur Institute for the protection of the local population against rabies and smallpox. Inspired by theExpand
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Changes in miniature end‐plate potentials after brief nervous stimulation at the frog neuromuscular junction.
The amplitude of miniature end‐plate potentials (m.e.p.p.s), recorded at the frog neuromuscular junction in a normal ionic environment and in absence of drugs, was examined following 10‐450 nerveExpand
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Sir Charles James Martin MB FRS: Australian serpents and Indian plague, one-hundred years ago.
  • B. Hawgood
  • Medicine
  • Toxicon : official journal of the International…
  • 1 July 1997
In 1891 as Demonstrator in Physiology at the University of Sydney, Charles Martin began the first systematic study of the chemical and physiological properties of the venoms of the Australian elapidExpand
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Waldemar Mordecai Haffkine, CIE (1860–1930): prophylactic vaccination against cholera and bubonic plague in British India
  • B. Hawgood
  • Medicine
  • Journal of medical biography
  • 1 February 2007
Waldemar Mordecai Haffkine developed an anticholera vaccine at the Pasteur Institute, Paris, in 1892. From the results of field trials in India from 1893 to 1896, he has been credited as havingExpand
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Specificity of antibodies to the reconstituted crotoxin complex, from the venom of South American rattlesnake (Crotalus durissus terrificus), using enzyme-linked immunosorbent assay (ELISA) and
Abstract Some differences between the reaction of antiserum to reconstituted crotoxin complex, to ‘native’ crotoxin and to whole Crotalus durissus terrificus (South American rattlesnake) venom wereExpand
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