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The pharmacophore of short cationic antibacterial peptides.
Cationic antibacterial peptides have been proclaimed as new drugs against multiresistant bacteria. Their limited success so far is partially due to the size of the peptides, which gives rise toExpand
Important structural features of 15-residue lactoferricin derivatives and methods for improvement of antimicrobial activity.
This review focuses on important structural features affecting the antimicrobial activity of 15-residue derivatives of lactoferricins. Our investigations are based on an alanine-scan of a 15-residueExpand
The role of tryptophan in the antibacterial activity of a 15‐residue bovine lactoferricin peptide
  • B. Haug, J. Svendsen
  • Chemistry, Medicine
  • Journal of peptide science : an official…
  • 1 April 2001
Bovine lactoferricin is a 25‐residue antibacterial peptide isolated after gastric cleavage of the iron transporting protein lactoferrin. A 15‐residue fragment, FKCRRWQWRMKKLGA of this peptideExpand
Bulky nonproteinogenic amino acids permit the design of very small and effective cationic antibacterial peptides.
The rate of multidrug-resistant infections is rapidly rising. Cationic antibacterial peptides are active against resistant pathogens and have low propensity for resistance development, but because ofExpand
Bulky aromatic amino acids increase the antibacterial activity of 15‐residue bovine lactoferricin derivatives
A model peptide, FKCRRWQWRMKKLGA, residues 17–31 of bovine lactoferricin, has been subjected to structure–antibacterial activity relationship studies. The two Trp residues are very important forExpand
Antimicrobial peptides with stability toward tryptic degradation.
The inherent instability of peptides toward metabolic degradation is an obstacle on the way toward bringing potential peptide drugs onto the market. Truncation can be one way to increase theExpand
Crystal Structure of the Golgi-Associated Human Nα-Acetyltransferase 60 Reveals the Molecular Determinants for Substrate-Specific Acetylation.
N-Terminal acetylation is a common and important protein modification catalyzed by N-terminal acetyltransferases (NATs). Six human NATs (NatA-NatF) contain one catalytic subunit each, Naa10 to Naa60,Expand
Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80
Significance N-terminal acetylation performed by N-terminal acetyltransferases (NATs) is a common protein modification in human cells. A unique NAT, NAA80, was recently found to control actinExpand
Pseudoaeruginosins, nonribosomal peptides in Nodularia spumigena.
Nodularia spumigena is a filamentous cyanobacterium that forms toxic blooms in brackish waters around the world through the production of the pentapeptide toxin nodularin. This cyanobacterium alsoExpand
Intramolecular hydrogen bonding in articaine can be related to superior bone tissue penetration: a molecular dynamics study.
Local anesthetics (LAs) are drugs that cause reversible loss of nociception during surgical procedures. Articaine is a commonly used LA in dentistry that has proven to be exceptionally effective inExpand
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