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p300 is a component of an estrogen receptor coactivator complex.
TLDR
It is found that the transcriptional coactivator p300 associates with agonist bound ER and augments ligand-dependent activation by ER, suggesting p300 functions as a point of integration between ER and these other pathways. Expand
Inhibition of estrogen receptor action by the orphan receptor SHP (short heterodimer partner).
TLDR
It is shown that SHP also interacts with estrogen receptors and inhibits their function, suggesting that it functions to regulate estrogen signaling through a direct interaction with ERalpha. Expand
Insights into the molecular biology of the estrogen receptor define novel therapeutic targets for breast cancer.
TLDR
The molecular mechanisms through which ER activates transcription of target genes and through which available anti-estrogens mediate their therapeutic effects are reviewed. Expand
Functional analysis of a novel estrogen receptor-beta isoform.
TLDR
In cotransfection experiments with expression plasmids for ERalpha, ERbeta1, and ERbeta2 and an estrogen-responsive element-containing luciferase reporter, the dose response of ER beta1 to E2 was similar to that of ERalpha although the maximal stimulation was approximately 50%. Expand
Ribosomal subunit kinase-2 is required for growth factor-stimulated transcription of the c-Fos gene.
TLDR
Rsk-2 is required for growth factor-stimulated expression of c-Fos and transcriptional activation of Elk-1 and the serum response factor, but not for activation of CREB or the mitogen-activated protein kinase pathway in response to PDGF and IGF-1 stimulation. Expand
Functional analysis of a novel estrogen receptor-beta isoform.
A new level of complexity has recently been added to estrogen signaling with the identification of a second estrogen receptor, ERb. By screening a rat prostate cDNA library, we detected ERb as wellExpand
Gene amplification and expression of the steroid receptor coactivator SRC3 (AIB1) in sporadic breast and endometrial carcinomas.
TLDR
Gene amplification was not found in any of the breast and endometrial carcinomas, but was found in the carcinoma cell lines MCF7 (10-fold) and HeLa (3-fold). Expand
Role of tyrosine kinase signaling in estrogen-induced LDL receptor gene expression in HepG2 cells.
TLDR
Assessment of whether estrogen-stimulated transcription of the LDL-r gene depends on tyrosine kinase (TK) and protein kinase C (PKC) activation, both signaling pathways being activated by estrogen in vivo and in hepatoma cells demonstrates that the induction of LDL- r expression by estrogen requires longer stimulation than that necessary for complement induction. Expand
Estrogen receptor-α and Sp1 interact in the induction of the low density lipoprotein-receptor
Both estrogen and selective estrogen receptor modulators (SERMs) such as tamoxifen and raloxifene have been demonstrated to lower plasma low density lipoprotein (LDL)-cholesterol concentrations byExpand
Molecular mechanism of estrogen receptor (ER)α-specific, estradiol-dependent expression of the progesterone receptor (PR) B-isoform
TLDR
It is concluded that PRB expression is stimulated by ERalpha but not ERbeta in an unique, AF1-dependent but AF2-independent mechanism. Expand
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