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Expression and changes of galanin in neurons and microglia in the hippocampus after transient forebrain ischemia in gerbils
TLDR
The results suggest that the early increase of GAL in the CA1 pyramidal cells may be associated with the reduction of the excitotoxic damage, that long-lasting enhanced expression of endogenous GAL at 12 h-2 days after ischemia may be related with efflux of potassium ion into the extracellular space, and that GAL expression in microglia 4 days afterIschemic damage may beassociated with reduction of ischemicdamage. Expand
Ischemia-related changes of glial-derived neurotrophic factor and phosphatidylinositol 3-kinase in the hippocampus: Their possible correlation in astrocytes
TLDR
Western blotting showed that ischemia-related changes of GDNF and PI-3 kinase protein levels were similar to the immunohistochemical changes after ischemIA, suggesting thatGDNF andPI-3 Kinase may be related to delayed neuronal death and that GDNFand PI- 3 kinases may be involved in activation of astrocytes. Expand
Glucose deprivation increases hydrogen peroxide level in immunostimulated rat primary astrocytes
TLDR
It is strongly indicated that glucose deprivation causes deterioration of immunostimulated astrocytes by increasing the intracellular concentration of H2O2. Expand
Evidence that protease-activated receptor-2 mediates trypsin-induced reversal of stellation in cultured rat astrocytes
TLDR
Results suggest that activation of PAR-2 by trypsin caused reversal of stellation in cultured astrocytes, in part, via the mobilization of intracellular Ca2+ and activation of PKC. Expand
Role of MAPK/ERK1/2 in the glucose deprivation-induced death in immunostimulated astroglia
TLDR
The role of the ERK1/2 signaling pathways play an important role in glucose deprivation-induced death in immunostimulated astroglia by regulating the generation of NO, superoxide and their reaction product, peroxynitrite. Expand
Tyrosine kinase A but not phosphacan/protein tyrosine phosphatase-ζ/β immunoreactivity and protein level changes in neurons and astrocytes in the gerbil hippocampus proper after transient forebrain
TLDR
The results suggest that chronological changes of trkA after transient forebrain ischemia may be associated with an ischemic damage compensatory mechanism in CA1 pyramidal cells. Expand
Na+/Ca2+ exchanger 1 alters in pyramidal cells and expresses in astrocytes of the gerbil hippocampal CA1 region after ischemia
TLDR
The results suggest that changes in NCX1 in CA1 pyramidal cells and astrocytes after ischemia are associated with intracellular Na(+) concentrations and thatNCX1 may induce an intrACEllular calcium overload, which may be related to neuronal death. Expand
Protein disulfide isomerase immunoreactivity and protein level changes in neurons and astrocytes in the gerbil hippocampal CA1 region following transient ischemia
TLDR
The findings suggest that increase of PDI in pyramidal cells may play a critical role in resistance to ischemic damage at early time after isChemic insult, and that expression of this protein in astrocytes at late time afterIschemic insult is partly implicated in the acquisition of tolerance against ischewichmic stress. Expand
Expression and changes of Ca2+-ATPase in neurons and astrocytes in the gerbil hippocampus after transient forebrain ischemia
TLDR
The results suggest that Ca2+-ATPase changes may be associated with a response to ischemic damage in hippocampal CA1 pyramidal cells, and that increased Ca2- ATPase immunoreactivity in the reactive astrocytes may beassociated with the maintenance of intracellular calcium levels. Expand