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GJB2 mutation spectrum in 2063 Chinese patients with nonsyndromic hearing impairment
BackgroundMutations in GJB2 are the most common molecular defects responsible for autosomal recessive nonsyndromic hearing impairment (NSHI). The mutation spectra of this gene vary among differentExpand
Src protein tyrosine kinase family and acute inflammatory responses.
Acute inflammatory responses are one of the major underlying mechanisms for tissue damage of multiple diseases, such as ischemia-reperfusion injury, sepsis, and acute lung injury. By use of cellularExpand
TNFα-Induced Long Pentraxin PTX3 Expression in Human Lung Epithelial Cells via JNK
Long pentraxin 3 (PTX3), an acute-phase protein, is a newly clarified mediator for innate immunity and inflammation. As a soluble pattern recognition receptor, it has a nonredundant role inExpand
Conversion of Mechanical Force into Biochemical Signaling*
Physical forces play important roles in regulating cell proliferation, differentiation, and death by activating intracellular signal transduction pathways. How cells sense mechanical stimulation,Expand
Migration of bone marrow‐derived mesenchymal stem cells induced by tumor necrosis factor‐α and its possible role in wound healing
We aimed to investigate the effect of tumor necrosis factor‐α (TNF‐α) on the expression of intercellular adhesion molecule‐1 (ICAM‐1) and vascular cell adhesion molecule‐1 (VCAM‐1) in the migrationExpand
XB130, a Novel Adaptor Protein for Signal Transduction*
Adaptor proteins are important mediators in signal transduction. In the present study, we report the cloning and characterization of a novel adaptor protein, XB130. This gene is located on humanExpand
Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: implications for cerebral ischemic stroke
ABSTRACT Circular RNAs (circRNAs) are highly expressed in the central nervous system and are involved in the regulation of physiological and pathophysiological processes. However, the potential roleExpand
Long pentraxin 3 in pulmonary infection and acute lung injury.
Long pentraxin 3 (PTX3) is a newly discovered acute phase protein produced at the sites of infection and inflammation by tissue cells, macrophages, monocytes, and dendritic cells. PTX3 plays anExpand
Clinical significance of detecting elevated serum DcR3/TR6/M68 in malignant tumor patients
TR6/DcR3/M68 is a soluble receptor that belongs to the TNF receptor family. It is expressed in malignant cells of several tumor types and has been postulated to help tumor cells to gain survivalExpand
Mechanical stress induces lung fibrosis by epithelial–mesenchymal transition*
Objectives: Many mechanically ventilated patients with acute respiratory distress syndrome develop pulmonary fibrosis. Stresses induced by mechanical ventilation may explain the development ofExpand