Biology and biochemistry of glucosinolates.
- B. Halkier, J. Gershenzon
- BiologyAnnual Review of Plant Biology
- 2 May 2006
Glucosinolates are sulfur-rich, anionic natural products that upon hydrolysis by endogenous thioglucosidases called myrosinases produce several different products that function as cancer-preventing agents, biopesticides, and flavor compounds.
Biosynthesis of glucosinolates--gene discovery and beyond.
- I. Sønderby, F. Geu-Flores, B. Halkier
- BiologyTrends in Plant Science
- 1 May 2010
Arabidopsis mutants in the C-S lyase of glucosinolate biosynthesis establish a critical role for indole-3-acetaldoxime in auxin homeostasis.
- M. D. Mikkelsen, P. Naur, B. Halkier
- BiologyThe Plant Journal
- 1 March 2004
The abolishment of glucosinolates in sur1 indicates that the SUR1 function is not redundant and thus SUR1 constitutes a single gene family, and provides important insight to the critical role IAOx plays in auxin homeostasis as a key branching point between primary and secondary metabolism, and defines a framework for further dissection of auxin biosynthesis.
Glucosinolate research in the Arabidopsis era.
- U. Wittstock, B. Halkier
- Environmental ScienceTrends in Plant Science
- 1 June 2002
Cytochrome P450 CYP79B2 from Arabidopsis Catalyzes the Conversion of Tryptophan to Indole-3-acetaldoxime, a Precursor of Indole Glucosinolates and Indole-3-acetic Acid*
- M. D. Mikkelsen, C. Hansen, U. Wittstock, B. Halkier
- BiologyJournal of Biological Chemistry
- 27 October 2000
The data show that oxime production by CYP79s is not restricted to those amino acids that are precursors for cyanogenic glucosides, which is consistent with the hypothesis that indole glucosinolates have evolved from cyanogenesis.
Modulation of CYP79 Genes and Glucosinolate Profiles in Arabidopsis by Defense Signaling Pathways1
- M. D. Mikkelsen, B. Petersen, E. Glawischnig, A. B. Jensen, E. Andreasson, B. Halkier
- ChemistryPlant Physiology
- 1 January 2003
The present data indicate that different indole glucos inolate methoxylating enzymes are induced by the jasmonate and the SA signal transduction pathways, whereas the aliphatic glucosinolates appear to be primarily genetically and not environmentally controlled.
A Systems Biology Approach Identifies a R2R3 MYB Gene Subfamily with Distinct and Overlapping Functions in Regulation of Aliphatic Glucosinolates
- I. Sønderby, B. G. Hansen, Nanna Bjarnholt, C. Ticconi, B. Halkier, D. Kliebenstein
- BiologyPLoS ONE
- 19 December 2007
Three R2R3 MYB transcription factors regulating aliphatic glucosinolate biosynthesis in Arabidopsis provide a unique system within which to study the evolution of MYB regulatory factors and their downstream targets.
Advancing uracil-excision based cloning towards an ideal technique for cloning PCR fragments
- H. Nour-Eldin, B. G. Hansen, Morten H. H. Nørholm, J. Jensen, B. Halkier
- BiologyNucleic Acids Research
- 25 September 2006
The largely unused uracil-excision molecular cloning technique is advanced by identifying PfuCx as a compatible proof-reading DNA polymerase and by developing an improved vector design strategy.
A unified nomenclature of NITRATE TRANSPORTER 1/PEPTIDE TRANSPORTER family members in plants.
- S. Léran, Kranthi Varala, B. Lacombe
- BiologyTrends in Plant Science
- 2014
Arabidopsis Cytochrome P450 Monooxygenase 71A13 Catalyzes the Conversion of Indole-3-Acetaldoxime in Camalexin Synthesis[W]
- Majse Nafisi, S. Goregaoker, J. Glazebrook
- BiologyThe Plant Cell Online
- 1 June 2007
It is concluded that CYP71A13 catalyzes the conversion of IAOx to IAN in camalexin synthesis and provide further support for the role of camaleXin in resistance to A. brassicicola.
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