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ortho-Substituent effects on the in vitro and in vivo genotoxicity of benzidine derivatives.
Benzidine and its 3,3'-diamino, 3,3'-dimethyl, 3,3'-dimethoxy, 3,3'-difluoro, 3,3'-dichloro, 3,3'-dibromo, 3,3'-dicarbomethoxy and 3,3'-dinitro derivatives together with 2-nitrobenzidine andExpand
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Substituent effects on the genotoxicity of 4-nitrostilbene derivatives.
4-Nitrostilbene and twelve of its derivatives (eleven E-stilbenes and two Z-stilbenes) were examined for possible quantitative structure-activity relationships of their in vitro and in vivoExpand
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Substituent effects on the mutagenicity of phenyl glycidyl ethers in Salmonella typhimurium
Phenyl glycidyl ether and 6 para-substituted derivatives, the methoxy, tert-butyl, methyl, chloro, bromo and nitro compounds, were tested in the Ames' test for mutagenicity. With the exception of theExpand
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The genotoxicity of enantiomeric aliphatic epoxides.
The (R)- and (S)-optical isomers of 9 epoxides, benzyloxymethyloxirane, epichlorohydrin, glycidol, glycidyl 3-nitrobenzenesulfonate, glycidyl 4-nitrobenzoate, glycidyl tosylate, styrene oxide,Expand
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Reactivity of mutagenic propylene oxides with deoxynucleosides and DNA.
In an extension of previous studies with deoxycytidine and thymidine reactivities, propylene oxide, glycidol, epichlorohydrin, and trichloropropylene oxide were reacted with deoxyguanosine as well asExpand
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DNA strand breaks in liver for four aliphatic epoxides in mice.
Four aliphatic epoxides, 1-naphthyl glycidyl ether (NGE), 1-naphthylpropylene oxide (NPO), 4-nitrophenyl glycidyl ether (NPGE), 3,3,3-trichloropropylene oxide (TCPO) and two of their precursors,Expand
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Detoxication of aliphatic epoxides by diol formation and glutathione conjugation.
The Ames procedure with Salmonella typhimurium strain TA100 was used to follow the detoxication by rat liver fractions of two series of aliphatic epoxides. The epoxides employed were 3-chloro-,Expand
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The in vivo and in vitro genotoxicity of aromatic amines in relationship to the genotoxicity of benzidine.
Benzidine and 12 related aromatic amines have been studied for the effects of substituent groups and pi orbital conjugation on their genotoxicity as measured by their mutagenicity in vitro withExpand
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Substituent effects on the in vitro and in vivo genotoxicity of 4-aminobiphenyl and 4-aminostilbene derivatives.
4-Amino-4'-substituted biphenyls and 4-aminostilbenes substituted in the 3' or 4' position were studied for their in vitro and in vivo genotoxicity. The in vitro mutagenicity of the biphenyls withExpand
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Mutagenicity of para-substituted α-methylstyrene oxide derivatives with Salmonella
Abstract A series of 5 para-substituted α-methylstyrene oxide derivatives have been synthesized and together with α-methylstyrene oxide as well as styrene oxide have been studied as to theirExpand
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