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Structural studies of the Vibrio cholerae O-antigen.
TLDR
Treatment of the N-deacylated polysaccharide with nitrous acid caused deamination with concomitant rearrangements, typical of 4-amino-4-deoxyhexopyranosyl residues in which the amino group occupies an equatorial position.
Safety and immunogenicity of an improved oral inactivated multivalent enterotoxigenic Escherichia coli (ETEC) vaccine administered alone and together with dmLT adjuvant in a double-blind, randomized,
TLDR
The new oral vaccine against enterotoxigenic Escherichia coli was safe and broadly immunogenic and dmLT further enhanced mucosal immune responses to CF antigens present in low amounts in the vaccine.
Randomised, double-blind, safety and efficacy of a killed oral vaccine for enterotoxigenic E. Coli diarrhoea of travellers to Guatemala and Mexico.
TLDR
It is concluded that the new oral ETEC vaccine reduces the rate of more severe episodes of traveller's diarrhoea (TD) due to VPO-ETEC, but it did not reduce the overall rate of ETEC diarrhea or of travellers' diarrhoeas due to other causes.
Prevalence of Norovirus among Visitors from the United States to Mexico and Guatemala Who Experience Traveler's Diarrhea
TLDR
It is suggested that NoV infection is a frequent occurrence among travelers to Mexico and Guatemala who experience episodes of TD, and the simple molecular detection method utilized here will serve to facilitate more in-depth epidemiological studies of this emergent viral pathogen in travelers and other at-risk populations.
Clinical trial to evaluate safety and immunogenicity of an oral inactivated enterotoxigenic Escherichia coli prototype vaccine containing CFA/I overexpressing bacteria and recombinantly produced
TLDR
It is demonstrated that CF over-expression and inclusion of the LCTBA hybrid protein in an oral inactivated ETEC vaccine does not change the safety profile when compared to a previous generation of such a vaccine and that the prototype vaccine induces significant dose dependent mucosal immune responses against CFA/I and LTB.
Immunological characterization of Vibrio cholerae O:1 lipopolysaccharide, O-side chain, and core with monoclonal antibodies
TLDR
The results indicate that the 9,000-molecular-weight fragment represents the complete polysaccharide chain, including group- and type-specific antigens as well as core antIGens, whereas the 900-molescular- Weight fragment constitutes the main part of the core region.
Monoclonal antibodies against group- and type-specific lipopolysaccharide antigens of Vibrio cholerae O:1
TLDR
Hybrid cell lines producing monoclonal antibodies against the O-antigenic determinants of Vibrio cholerae O:1 have been established and had a good agglutinating capacity when tested against V. cholera O:2 and O:21 strains.
Detection of the response regulator AgrA in the cytosolic fraction of Staphylococcus aureus by monoclonal antibodies.
TLDR
The overexpression and purification of the response regulator, AgrA is described and previous results obtained with protein extracts from agr+ and agr- cells are confirmed.
Monoclonal antibody-based enzyme-linked immunosorbent assays for identification and serotyping of Vibrio cholerae O1
  • B. Gustafsson
  • Biology, Medicine
    Journal of clinical microbiology
  • 1 December 1984
TLDR
Monoclonal antibodies directed against O-specific antigens of Vibrio cholerae O1 lipopolysaccharide were used in two different enzyme-linked immunosorbent assays (ELISAs), designed for identification and serotyping of V. cholerai O1, and were shown to be useful in slide agglutination tests.
Rapid detection of Bordetella pertussis by a monoclonal antibody-based colony blot assay
TLDR
Monoclonal antibodies to Bordetella pertussis filamentous hemagglutinin (FHA) and lipopolysaccharide (LPS) were used in a colony blot enzyme-linked immunosorbent assay designed for rapid detection of B. pertussi and B. parapertussis in suspected cases of whooping cough.
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