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Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis
A variety of cell adhesion mechanisms underlie the way that cells are organized in tissues. Stable cell interactions are needed to maintain the structural integrity of tissues, and dynamic changes inExpand
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Regulation of cadherin-mediated adhesion in morphogenesis
  • B. Gumbiner
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • 1 August 2005
Cadherin cell-adhesion proteins mediate many facets of tissue morphogenesis. The dynamic regulation of cadherins in response to various extracellular signals controls cell sorting, cellExpand
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C-Cadherin Ectodomain Structure and Implications for Cell Adhesion Mechanisms
Cadherins are transmembrane proteins that mediate adhesion between cells in the solid tissues of animals. Here we present the 3.1 angstrom resolution crystal structure of the whole, functionalExpand
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The Mouse FusedLocus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation
Mutations at the mouse Fused locus have pleiotropic developmental effects, including the formation of axial duplications in homozygous embryos. The product of the Fused locus, Axin, displaysExpand
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Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1.
ZO-1 is a 210- to 220-kDa peripheral membrane protein associated with the cytoplasmic surface of the epithelial tight junction. Because ZO-1 may interact with other unidentified tight junctionExpand
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E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components
Contact inhibition of cell growth is essential for embryonic development and maintenance of tissue architecture in adult organisms, and the growth of tumors is characterized by a loss of contactExpand
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Cadherin Engagement Regulates Rho family GTPases*
The formation of cell-cell adherens junctions is a cadherin-mediated process associated with reorganization of the actin cytoskeleton. Because Rho family GTPases regulate actin dynamics, weExpand
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Embryonic axis induction by the armadillo repeat domain of beta- catenin: evidence for intracellular signaling
beta-catenin was identified as a cytoplasmic cadherin-associated protein required for cadherin adhesive function (Nagafuchi, A., and M. Takeichi. 1989. Cell Regul. 1:37-44; Ozawa, M., H. Baribault,Expand
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The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex
The role of the epithelial adhesion molecule uvomorulin in the formation of the epithelial junctional complex in the Madin-Darby canine kidney (MDCK) cell line was investigated. Experiments wereExpand
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Regulation of Cadherin Adhesive Activity
  • B. Gumbiner
  • Medicine, Biology
  • The Journal of cell biology
  • 7 February 2000
Adhesive interactions between cells are dynamic and regulated during tissue development and homeostasis. Cadherins are major cell–cell adhesion molecules involved in the development and maintenanceExpand
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