• Publications
  • Influence
Regulation of cadherin-mediated adhesion in morphogenesis
  • B. Gumbiner
  • Biology, Medicine
    Nature Reviews Molecular Cell Biology
  • 1 August 2005
Cadherin cell-adhesion proteins mediate many facets of tissue morphogenesis. The dynamic regulation of cadherins in response to various extracellular signals controls cell sorting, cell
C-Cadherin Ectodomain Structure and Implications for Cell Adhesion Mechanisms
TLDR
The 3.1 angstrom resolution crystal structure of the whole, functional extracellular domain from C-cadherin is presented, a representative “classical” cadherin that suggests a molecular mechanism for adhesion between cells by classical cadherins and provides a new framework for understanding both cis (same cell) and trans (juxtaposed cell) caderin interactions.
A single amino acid in E‐cadherin responsible for host specificity towards the human pathogen Listeria monocytogenes
Human E‐cadherin promotes entry of the bacterial pathogen Listeria monocytogenes into mammalian cells by interacting with internalin (InlA), a bacterial surface protein. Here we show that mouse
E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components
TLDR
The results indicate that, in addition to its role in cell–cell adhesion, E-cadherin-mediated cell– cell contact directly regulates the Hippo signaling pathway to control cell proliferation.
Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1.
TLDR
It is proposed that the 160-kDa polypeptide identified that coimmunoprecipitates with ZO-1 from detergent extracts of metabolically labeled Madin-Darby canine kidney (MDCK) cells is a component of the tight junction.
Embryonic axis induction by the armadillo repeat domain of beta- catenin: evidence for intracellular signaling
TLDR
It is proposed that overexpression of beta-Catenin in the ventral side of the early Xenopus embryo, by injection of synthetic beta-catenin mRNA, induces the formation of a complete secondary body axis and that beta- catenin acts in this circumstance as an intracellular signaling molecule.
Cadherin Engagement Regulates Rho family GTPases*
TLDR
It is found that induction of cell-cell junctions increased Rac1 activity, and this was inhibited by E-cadherin function-blocking antibodies, and that cadherin-mediated adhesion regulates the activity of RhoA, Rac1, and Cdc42.
The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex
TLDR
The role of the epithelial adhesion molecule uvomorulin seems to mediate an early adhesion event between epithelial cells that is a prerequisite for the assembly of all elements of the junctional complex.
...
1
2
3
4
5
...