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The gut microbiota influences blood-brain barrier permeability in mice
- V. Braniste, M. Al-Asmakh, +15 authors S. Pettersson
- Biology, MedicineScience Translational Medicine
- 19 November 2014
It is shown that germ-free pregnant dams, devoid of maternal microbes, have offspring that show increased permeability of the blood-brain barrier, suggesting that crosstalk between the gut microbiota and the brain, initiated during the intrauterine period, is perpetuated throughout life.
Olfactory Functions Are Mediated by Parallel and Hierarchical Processing
Findings indicate that olfactory functions are organized in a parallel and hierarchical manner.
Activation by Attention of the Human Reticular Formation and Thalamic Intralaminar Nuclei
It has been known for over 45 years that electrical stimulation of the midbrain reticular formation and of the thalamic intralaminar nuclei of the brain alerts animals. However, lesions of these…
Smelling of Odorous Sex Hormone-like Compounds Causes Sex-Differentiated Hypothalamic Activations in Humans
It is shown that women smelling an androgen-like compound activate the hypothalamus, with the center of gravity in the preoptic and ventromedial nuclei, which suggests a potential physiological substrate for a sex-differentiated behavioral response in humans.
Visual memory, visual imagery, and visual recognition of large field patterns by the human brain: functional anatomy by positron emission tomography.
The areas of the human brain that changed rCBF during the storage, retrieval from long-term memory, and recognition of complex visual geometrical patterns were mapped to indicate that the ways by which the brain accesses the storage sites are different.
Role of sodium channel inhibition in neuroprotection: effect of vinpocetine
Positron emission tomography studies have proved that vinpocetine is able to redistribute regional cerebral blood flow and enhance glucose supply of brain tissue in ischemic post-stroke patients.
Odorant differentiated pattern of cerebral activation: Comparison of acetone and vanillin
The differentiated pattern of cerebral activation during odorant perception seems to be dependent on the signal transducing cranial nerves involved, andacetone's limited activation of the olfactory cortex may result from a cross‐modal interaction, with inhibition of acetone's odor component by its trigeminal component.
Response latencies of visual cells in macaque areas V1, V2 and V5
Extensive overlap of latencies in all 3 regions at both the high and low ends of their respective ranges indicates a considerable degree of parallel interaction between striate and extrastriate cortex.
Effect of amphetamine on dopamine D2 receptor binding in nonhuman primate brain: A comparison of the agonist radioligand [11C]MNPA and antagonist [11C]raclopride
PET measurements of stimulant‐induced dopamine (DA) release are typically performed with antagonist radioligands that bind to both the high‐ and low‐affinity state of the receptor. In contrast, an…
Preparation of highly specific radioactivity [18F]flumazenil and its evaluation in cynomolgus monkey by positron emission tomography.
- N. N. Ryzhikov, N. Seneca, +8 authors C. Halldin
- Chemistry, MedicineNuclear medicine and biology
- 1 February 2005
Human post-mortem whole-hemisphere autoradiography of brain sections demonstrated selective uptake of the radioligand in the areas of high density of the central benzodiazepine receptors (BZR) and PET studies in a cynomolgus monkey and metabolite studies by HPLC demonstrated similar results by [18F]flumazenil.