• Publications
  • Influence
Remifentanil-induced Postoperative Hyperalgesia and Its Prevention with Small-dose Ketamine
Background:Remifentanil-induced secondary hyperalgesia has been documented experimentally in both animals and healthy human volunteers, but never clinically. This study tested the hypotheses thatExpand
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Acute Opioid Tolerance: Intraoperative Remifentanil Increases Postoperative Pain and Morphine Requirement
Background Rapid development of acute opioid tolerance is well established in animals and is more likely to occur with large doses of short-acting drugs. The authors therefore tested the hypothesisExpand
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The Effect of Remifentanil on the Bispectral Index Change and Hemodynamic Responses After Orotracheal Intubation
In order to examine whether changes in the bispectral index (BIS) may be an adequate monitor for the analgesic component of anesthesia, we evaluated the effect of remifentanil on the BIS change andExpand
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Preoperative Gabapentin Decreases Anxiety and Improves Early Functional Recovery from Knee Surgery
Gabapentin has antihyperalgesic and anxiolytic properties. We thus tested the hypothesis that premedication with gabapentin would decrease preoperative anxiety and improve postoperative analgesia andExpand
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The Benefits of Intraoperative Small-Dose Ketamine on Postoperative Pain After Anterior Cruciate Ligament Repair
In a randomized, double-blinded study with three parallel groups, we assessed the analgesic effect of intraoperative ketamine administration in 45 ASA physical status I or II patients undergoingExpand
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Supplementing Desflurane-Remifentanil Anesthesia with Small-Dose Ketamine Reduces Perioperative Opioid Analgesic Requirements
Relative large-dose intraoperative remifentanil could lead to the need for more postoperative analgesics. Intraoperative N-methyl-d-aspartate receptor antagonists, such as ketamine, decreaseExpand
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Monitoring analgesia.
  • B. Guignard
  • Medicine
  • Best practice & research. Clinical…
  • 2006
Analgesia (pain relief) amnesia (loss of memory) and immobilisation are the three major components of anaesthesia. The perception of pain, and therefore, the need for analgesia, is individual, andExpand
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Intraoperative Small-Dose Ketamine Enhances Analgesia After Outpatient Knee Arthroscopy
Ketamine may prevent postoperative hyperalgesia. In patients undergoing arthroscopic meniscectomy using general anesthesia, we tested whether a single intraoperative dose of ketamine enhancedExpand
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Pulmonary Complications After Elective Liver Transplantation—Incidence, Risk Factors, and Outcome
&NA; After liver transplantation (LT), postoperative pulmonary complications (PPC) occur in approximately 35% to 50% of the recipients. Among these PPC, pneumonia is the most frequently encountered.Expand
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Esmolol prevents movement and attenuates the BIS response to orotracheal intubation.
BACKGROUND Beta-adrenergic agonists enhance behavioural and electroencephalographic arousal reactions. We explored whether adding esmolol, a short-acting beta(1)-adrenoceptor antagonist, to propofolExpand
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