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CD56dimCD16+ NK cells downregulate CD16 following target cell induced activation of matrix metalloproteinases
CD56 dim CD16 + NK cells downregulate CD16 following target cell induced activation of matrix metalloproteinases
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Coordinated acquisition of inhibitory and activating receptors and functional properties by developing human natural killer cells.
The stages of human natural killer (NK) cell differentiation are not well established. Culturing CD34(+) progenitors with interleukin 7 (IL-7), IL-15, stem cell factor (SCF), FLT-3L, and murine fetalExpand
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Human embryonic stem cells differentiate into a homogeneous population of natural killer cells with potent in vivo antitumor activity.
Natural killer (NK) cells serve as important effectors for antitumor immunity, and CD56+CD45+ NK cells can be routinely derived from human embryonic stem cells (hESCs). However, little is know aboutExpand
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Natural killer-cell differentiation by myeloid progenitors.
Because lymphoid progenitors can give rise to natural killer (NK) cells, NK ontogeny has been considered to be exclusively lymphoid. Here, we show that rare human CD34(+) hematopoietic progenitorsExpand
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Umbilical Cord Blood T Cells Express Multiple Natural Cytotoxicity Receptors after IL-15 Stimulation, but Only NKp30 Is Functional1
The natural cytotoxicity receptors (NCRs) NKp30, NKp44, and NKp46 are thought to be NK lineage restricted. Herein we show that IL-15 induces NCR expression on umbilical cord blood (UCB) T cells. NCRsExpand
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Phase I Study of a Bispecific Ligand-Directed Toxin Targeting CD22 and CD19 (DT2219) for Refractory B-cell Malignancies
Purpose: The novel bispecific ligand-directed toxin (BLT) DT2219 consists of a recombinant fusion between the catalytic and translocation enhancing domain of diphtheria toxin (DT) and bispecificExpand
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Lymphoid tissue fibrosis is associated with impaired vaccine responses
&NA; Vaccine responses vary by geographic location. We have previously described how HIV‐associated inflammation leads to fibrosis of secondary lymph nodes (LNs) and T cell depletion. We hypothesizedExpand
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B-cell posttransplant lymphoproliferative disorder isolated to the central nervous system is Epstein-Barr virus positive and lacks p53 and Myc expression by immunohistochemistry.
In this retrospective study from one institution, we performed a clinicopathological study of a cohort of patients with posttransplant lymphoproliferative disorder (PTLD) confined to the centralExpand
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Use of natural killer cells as immunotherapy for leukaemia.
Natural killer (NK) cells potentially play a significant role in eradicating residual disease following allogeneic haematopoietic cell transplantation, and have been explored as tools for adoptiveExpand
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Analysis of Peripheral T‐cell Lymphoma Diagnostic Workup in the United States
Micro‐Abstract With increased understanding of the unique entities of peripheral T‐cell lymphoma (PTCL), subtype‐specific approaches are emerging, and more precise diagnoses are becoming increasinglyExpand
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