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Rab27a and Rab27b control different steps of the exosome secretion pathway
The results therefore strengthen the link between MVEs and exosomes, and introduce ways of manipulating exosome secretion in vivo.
Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform
This study shows that membrane exchange between the early endocytic and the biosynthetic/secretory pathways involves specific components of the Rab and SNARE machinery, and suggests that retrograde transport between early/recycling endosomes and the endoplasmic reticulum is critically dependent on the sequential action of two members of therab6 subfamily.
Rab11 Regulates the Compartmentalization of Early Endosomes Required for Efficient Transport from Early Endosomes to the Trans-Golgi Network
- M. Wilcke, L. Johannes, T. Galli, V. Mayau, B. Goud, J. Salamero
- BiologyThe Journal of cell biology
- 11 December 2000
The results suggest that Rab11 influences endosome to TGN trafficking primarily by regulating membrane distribution inside the early endosomal pathway.
Bicaudal-D regulates COPI-independent Golgi–ER transport by recruiting the dynein–dynactin motor complex
It is suggested that coordinated action between Rab6a, BICD and the dynein–dynactin complex controls COPI-independent Golgi–ER transport.
Direct Pathway from Early/Recycling Endosomes to the Golgi Apparatus Revealed through the Study of Shiga Toxin B-fragment Transport
- F. Mallard, C. Antony, D. Tenza, J. Salamero, B. Goud, L. Johannes
- Biology, ChemistryThe Journal of cell biology
- 16 November 1998
It is hypothesized that Shiga toxin B-fragment is transported directly from early/recycling endosomes to the Golgi apparatus, using the same pathway used by cellular proteins.
Rab35 Regulates an Endocytic Recycling Pathway Essential for the Terminal Steps of Cytokinesis
Noninvasive measurement of the pH of the endoplasmic reticulum at rest and during calcium release.
- J. Kim, L. Johannes, S. Grinstein
- BiologyProceedings of the National Academy of Sciences…
- 17 March 1998
The pH of the endoplasmic reticulum is near neutral and is unaffected during agonist-induced release of calcium, and the ER was found to be highly permeable to H+ (equivalents), so that the prevailing [H+] is susceptible to alterations in the cytosolic pH.
The role of ARF and Rab GTPases in membrane transport.
Rab6 Coordinates a Novel Golgi to ER Retrograde Transport Pathway in Live Cells
Results indicate Rab6 regulates a novel Golgi to ER transport pathway, and fluorescent-protein (FP) fusion to Rab6, a Golgi-associated GTPase, in conjunction with fluorescent secretory pathway markers indicate this pathway is regulated by Rab6.
Protein interaction mapping: a Drosophila case study.
This work used a high-throughput yeast two-hybrid (Y2H)-based technology to screen 102 bait proteins from Drosophila melanogaster, most of them orthologous to human cancer-related and/or signaling proteins, against high-complexity fly cDNA libraries.