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Suppression of Amygdalar Endocannabinoid Signaling by Stress Contributes to Activation of the Hypothalamic-Pituitary-Adrenal Axis
Endocannabinoids inhibit hypothalamic–pituitary–adrenal (HPA) axis activity; however, the neural substrates and pathways subserving this effect are not well characterized. The amygdala is a forebrainExpand
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Regional alterations in the endocannabinoid system in an animal model of depression: effects of concurrent antidepressant treatment
It has been suggested that disturbances in endocannabinoid signaling contribute to the development of depressive illness; however, at present there is insufficient evidence to allow for a fullExpand
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Recruitment of Prefrontal Cortical Endocannabinoid Signaling by Glucocorticoids Contributes to Termination of the Stress Response
The mechanisms subserving the ability of glucocorticoid signaling within the medial prefrontal cortex (mPFC) to terminate stress-induced activation of the hypothalamic–pituitary–adrenal (HPA) axisExpand
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Pharmacological enhancement of cannabinoid CB1 receptor activity elicits an antidepressant-like response in the rat forced swim test
These experiments aimed to assess whether enhanced activity at the cannabinoid CB1 receptor elicits antidepressant-like effects. To examine this we administered 1 and 5 mg/kg doses of theExpand
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Downregulation of Endocannabinoid Signaling in the Hippocampus Following Chronic Unpredictable Stress
Deficits in cognitive functioning and flexibility are seen following both chronic stress and modulation of endogenous cannabinoid (eCB) signaling. Here, we investigated whether alterations in eCBExpand
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Serum endocannabinoid content is altered in females with depressive disorders: a preliminary report.
BACKGROUND Preclinical research has suggested that the endocannabinoid system may be involved in the etiology and/or treatment of depression; however, there are no published studies examiningExpand
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Neurobiology of chronic mild stress: Parallels to major depression
The chronic mild (or unpredictable/variable) stress (CMS) model was developed as an animal model of depression more than 20 years ago. The foundation of this model was that following long-termExpand
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The enhancing effects of anxiety on arousal in sexually dysfunctional and functional women.
Effects of anxiety on sexual arousal were examined to determine if sexually dysfunctional and functional women exhibit different patterns of physiological and subjective response. Subjects viewed 2Expand
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Acculturation and Sexual Function in Asian Women
Cultural effects on sexuality are pervasive and potentially of great clinical importance, but have not yet received sustained empirical attention. The purpose of this study was to explore the role ofExpand
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Asian and Non-Asian Attitudes Toward Rape, Sexual Harassment, and Sexuality
The purpose of this study was to explore potential differences between Asian and non-Asian university students in attitudes toward coercive and noncoercive sexual behavior. Four hundred women and menExpand
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