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Suppression of Amygdalar Endocannabinoid Signaling by Stress Contributes to Activation of the Hypothalamic-Pituitary-Adrenal Axis
TLDR
Findings suggest that the degree to which stressful stimuli reduce amygdalar AEA/CB1 receptor signaling contributes to the magnitude of the HPA response.
Endogenous cannabinoid signaling is essential for stress adaptation
TLDR
An important role for endocannabinoid signaling is demonstrated in the process of stress HPA habituation, and it is suggested that AEA and 2-AG modulate different components of the adrenocortical response to repeated stressor exposure.
Regional alterations in the endocannabinoid system in an animal model of depression: effects of concurrent antidepressant treatment
TLDR
The data suggest that the endocannabinoid system in cortical and subcortical structures is differentially altered in an animal model of depression and that the effects of CUS on CB1 receptor binding site density are attenuated by antidepressant treatment while those on endOCannabinoid content are not.
Downregulation of Endocannabinoid Signaling in the Hippocampus Following Chronic Unpredictable Stress
TLDR
The data suggest that stress-induced downregulation of hippocampal eCB signaling contributes to problems in behavioral flexibility and could play a role in the development of perseveratory and ruminatory behaviors in stress-related neuropsychiatric disorders.
Recruitment of Prefrontal Cortical Endocannabinoid Signaling by Glucocorticoids Contributes to Termination of the Stress Response
TLDR
The ability of stress-induced glucocorticoid signaling within mPFC to terminate HPA axis activity is mediated by a local recruitment of endocannabinoid signaling, which supports a model in which endoc cannabinoidoid receptor engagement to activation of corticolimbic relays that inhibit corticosterone secretion.
Serum endocannabinoid content is altered in females with depressive disorders: a preliminary report.
TLDR
These are the first clinical data to indicate that the endocannabinoid system may be disturbed in affective disease, and suggest that future research is required to determine the relevance of these changes with respect to disease manifestation and pharmacotherapy.
Pharmacological enhancement of cannabinoid CB1 receptor activity elicits an antidepressant-like response in the rat forced swim test
TLDR
The data suggest that enhancement of CB1 receptor signaling results in antidepressant effects in the forced swim test similar to that seen following conventional antidepressant administration.
Neurobiology of chronic mild stress: Parallels to major depression
TLDR
The chronic mild stress paradigm evokes an array of neurobiological changes that mirror those seen in depressive disorders and may be a suitable tool to investigate novel systems that could be disturbed in depression, and thus aid in the development of novel targets for the treatment of depression.
Acculturation and Sexual Function in Asian Women
TLDR
The role of acculturation on sexual permissiveness and sexual function in Asian women living in Canada is explored, with a particular focus on arousal, to suggest that measurement of Acculturation may capture information about an individual's unique accULTuration pattern that is not evident when focusing solely on ethnic group comparisons or length of residency.
The enhancing effects of anxiety on arousal in sexually dysfunctional and functional women.
TLDR
Effects of anxiety on sexual arousal were examined to determine if sexually dysfunctional and functional women exhibit different patterns of physiological and subjective response, and mechanisms by which sympathetic activation enhances sexual arousal.
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