B. Goeke

Publications207
h-index16
Citations1,600
Highly Influential Citations63
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International Union of Pharmacology. XXXV. The Glucagon Receptor Family
Peptide hormones within the secretin-glucagon family are expressed in endocrine cells of the pancreas and gastrointestinal epithelium and in specialized neurons in the brain, and subserve multiple… Expand
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Exendin(9-39)amide is an antagonist of glucagon-like peptide-1(7-36)amide in humans.
The gastrointestinal hormone, glucagon-like peptide-1(7-36)amide (GLP-1) is released after a meal. The potency of synthetic GLP-1 in stimulating insulin secretion and in inhibiting glucagon secretion… Expand
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GLP-1 stimulates secretion of macromolecules from airways and relaxes pulmonary artery.
Recent data revealed the existence of specific receptors for glucagon-like peptide-1(7-36)amide (GLP-1) on rat lung membranes. Utilizing slide-mount autoradiography of fresh frozen lung tissue… Expand
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Two functionally distinct cholecystokinin receptors show different modes of action on Ca2+ mobilization and phospholipid hydrolysis in isolated rat pancreatic acini. Studies using a new…
A new hepatapeptide cholecystokinin (CCK) analog, JMV-180 (Boc-Tyr(SO3-)-Nle-Gly-Trp-Nle-Asp-2-phenylethylester), acts as an agonist at high affinity CCK receptors on rat pancreatic acini to… Expand
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GLP-1-induced alterations in the glucose-stimulated insulin secretory dose-response curve.
The present study was undertaken to establish in normal volunteers the alterations in beta-cell responsiveness to glucose associated with a constant infusion of glucagon-like peptide-1 (GLP-1) or a… Expand
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Glucose-dependency of the insulin stimulatory effect of glucagon-like peptide-1 (7–36) amide on the rat pancreas
The glucose-dependent action of GLP-1 (7–36) amide (GLP-1) on insulin secretion was studied in isolated islets and in the perfused rat pancreas. In islet experiments in the presence of… Expand
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Rat gastric somatostatin and gastrin release: interactions of exendin-4 and truncated glucagon-like peptide-1 (GLP-1) amide.
The effect of exendin-4, a peptide of the secretin-glucagon family with high homology of amino acid sequence with glucagon-like peptide-1 (GLP-1), on gastric hormone release was investigated in the… Expand
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Glycosylation of the GLP-1 receptor is a prerequisite for regular receptor function
The GLP-1 receptor on RINm5F cells is a glycoprotein with a M(r) of 63,000. Treatment of the receptor with glycopeptidase F generated a protein with a M(r) of 51,000, indicating that the GLP-1… Expand
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Characterization of receptors for glucagon‐like peptide‐1(7–36) amide on rat lung membranes
Specific binding of 125I‐labelled GLP‐1(7–36)amide to rat lung membranes was dependent upon time and temperature and was proportional to membrane protein concentration. Binding was inhibited in a… Expand
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A nutrient-regulated cytosolic calcium oscillator in endocrine pancreatic glucagon-secreting cells
Abstract We investigated the influence of nutrients on spontaneous cytosolic calcium oscillations in InR1-G9 glucagonoma cells, a model for pancreatic α-cells. The oscillations depended on calcium… Expand
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