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Synthesis of peptides and pyrazines from β-amino alcohols through extrusion of H2 catalyzed by ruthenium pincer complexes: ligand-controlled selectivity.
A novel method for peptide synthesis is reported, which involves dehydrogenative coupling of b-amino alcohols with extrusion of H2 catalyzed by complex 1 and environmentally benign and atom-economical reaction proceeds under neutral reaction conditions without the use of toxic reagents, activators, condensing agents, or other additives.
Synthesis of polyamides from diols and diamines with liberation of H2
The amidation reaction based on catalytic coupling of alcohols with amines previously reported by us, using the pincer complexes 1 and 2 as catalysts, was applied to the generation of polyamides from
Direct synthesis of imines from alcohols and amines with liberation of H2.
A general, efficient, and environmentally benign method for the direct synthesis of imines by the reaction of alcohols with amines is reported, which occurs with liberation of H2 gas and water, high turnover numbers, and no waste products.
Direct hydrogenation of amides to alcohols and amines under mild conditions.
The selective, direct hydrogenation of amides to the corresponding alcohols and amines with cleavage of the C-N bond was discovered. The expected products of C-O cleavage are not formed (except as
Synthesis of amides from esters and amines with liberation of H2 under neutral conditions.
A mechanism is proposed involving metal-ligand cooperation via aromatization-dearomatization of the pyridine moiety and hemilability of the amine arm ofThe pincer ligand, achieving efficient synthesis of amides directly from esters and amines with the liberation of molecular hydrogen.
Ruthenium Pincer‐Catalyzed Cross‐Dehydrogenative Coupling of Primary Alcohols with Secondary Alcohols under Neutral Conditions
Cross-dehydrogenative coupling of primary alcohols with secondary alcohols to obtain mixed esters with the liberation of molecular hydrogen is achieved in high yield and good selectivity under
"Long-range" metal-ligand cooperation in H2 activation and ammonia-promoted hydride transfer with a ruthenium-acridine pincer complex.
Ammonia induces transfer of a hydride from the Ru center of 1 to C9 of the flexible acridine pincer ligand, forming an unusual dearomatized fac-acridine PNP complex.
Recent Advances in the Metal-Catalyzed Activation of Amide Bonds.
This Focus Review discusses the recent advances in this area and presents a summary of methods that have been developed for activating the amide N-C bond by using precious and non-precious metals.
Transition-Metal-Free C-H Hydroxylation of Carbonyl Compounds.
A preliminary mechanistic investigation, supported by isotope labeling and computational studies, suggests the formation of a peroxide bond and its cleavage by in situ generated enolate in transition metal and reductant free α-C(sp3)-H hydroxylation of carbonyl compounds.
Iron-Catalyzed Batch/Continuous Flow C-H Functionalization Module for the Synthesis of Anticancer Peroxides.
Iron-catalyzed dehydrogenative cross-coupling of carbonyl compounds with aliphatic peroxide was developed under mild conditions and found to exhibit the good anticancer activity with minimum IC50= 5.3 μM.