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Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial
TLDR
Perioperative chemotherapy with FOLFOX4 is compatible with major liver surgery and reduces the risk of events of progression-free survival in eligible and resected patients. Expand
A pathology atlas of the human cancer transcriptome
TLDR
A Human Pathology Atlas has been created as part of the Human Protein Atlas program to explore the prognostic role of each protein-coding gene in 17 different cancers, and reveals that gene expression of individual tumors within a particular cancer varied considerably and could exceed the variation observed between distinct cancer types. Expand
ESMO Consensus Guidelines for management of patients with colon and rectal cancer. a personalized approach to clinical decision making.
TLDR
This ESMO guideline is recommended to be used as the basis for treatment and management decisions, delivering a clear proposal for diagnostic and treatment measures in each stage of rectal and colon cancer and the individual clinical situations. Expand
Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial
TLDR
The adjuvant combination of gem citabine and capecitabine should be the new standard of care following resection for pancreatic ductal adenocarcinoma. Expand
Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trial.
TLDR
Preoperative short-term radiotherapy significantly improved 10-year survival in patients with a negative circumferential margin and TNM stage III, and future staging techniques should offer possibilities to select patient groups for which the balance between benefits and side-effects will result in sufficiently large gains. Expand
Autoimmune and chronic inflammatory disorders and risk of non-Hodgkin lymphoma by subtype.
TLDR
These NHL subtypes develop during postantigen exposure stages of lymphocyte differentiation, consistent with a role of antigenic drive in autoimmunity-related lymphomagenesis, suggest that the associations may not be general but rather mediated through specific NHL subtype. Expand
The TME Trial After a Median Follow-up of 6 Years: Increased Local Control But No Survival Benefit in Irradiated Patients With Resectable Rectal Carcinoma
TLDR
There is a persisting overall effect of preoperative short-term radiotherapy on local control in patients with clinically resectable rectal cancer, however, there is no effect on overall survival. Expand
Cancer risk following organ transplantation: a nationwide cohort study in Sweden
TLDR
In conclusion, organ transplantation entails a persistent, about four-fold increased overall cancer risk, and the complex pattern of excess risk at many sites challenges current understanding of oncogenic infections that might become activated by immunologic alterations. Expand
Breast cancer following radiotherapy and chemotherapy among young women with Hodgkin disease.
TLDR
Hormonal stimulation appears important for the development of radiation-induced breast cancer, as evidenced by the reduced risk associated with ovarian damage from alkylating agents or radiation. Expand
Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer.
TLDR
Short-term preoperative radiotherapy reduces the risk of local recurrence in patients with rectal cancer who undergo a standardized total mesorectal excision. Expand
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