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Guidelines for the use and interpretation of assays for monitoring autophagy
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered theExpand
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HERG, a human inward rectifier in the voltage-gated potassium channel family.
In contrast to other members of the Eag family of voltage-gated, outwardly rectifying potassium channels, the human eag-related gene (HERG) has now been shown to encode an inwardly rectifyingExpand
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A family of potassium channel genes related to eag in Drosophila and mammals.
We have identified a conserved family of genes related to Drosophila eag, which encodes a distinct type of voltage-activated K+ channel. Three related genes were recovered in screens of cDNAExpand
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Molecular analysis of the para locus, a sodium channel gene in Drosophila
Previous behavioral, electrophysiological, pharmacological, and genetic studies of mutations of the para locus in Drosophila melanogaster suggested that these mutations alter the structure orExpand
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A component of calcium-activated potassium channels encoded by the Drosophila slo locus.
Calcium-activated potassium channels mediate many biologically important functions in electrically excitable cells. Despite recent progress in the molecular analysis of voltage-activated K+ channels,Expand
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Synaptic Vesicle Size and Number Are Regulated by a Clathrin Adaptor Protein Required for Endocytosis
Clathrin-mediated endocytosis is thought to involve the activity of the clathrin adaptor protein AP180. However, the role of this protein in endocytosis in vivo remains unknown. Here, we show that aExpand
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Functional Expression of Drosophila para Sodium Channels : Modulation by the Membrane Protein TipE and Toxin Pharmacology
The Drosophila para sodium channel α subunit was expressed in Xenopus oocytes alone and in combination with tipE , a putative Drosophila sodium channel accessory subunit. Coexpression of tipE withExpand
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A Drosophila mutation that eliminates a calcium-dependent potassium current.
A mutation of Drosophila, slowpoke (slo), specifically abolishes a Ca2+-dependent K+ current, IC, from dorsal longitudinal flight muscles of adult flies. Other K+ currents remain normal, providingExpand
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Drosophila Ecdysone Receptor Mutations Reveal Functional Differences among Receptor Isoforms
The steroid hormone ecdysone directs Drosophila metamorphosis via three heterodimeric receptors that differ according to which of three ecdysone receptor isoforms encoded by the EcR gene (EcR-A,Expand
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Ion Channels and Synaptic Organization Analysis of the Drosophila Genome
The most obvious conclusion from this survey is that neuronal signaling proteins, for the most part, have been highly conserved throughout evolution. Despite the dramatic differences in complexityExpand
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