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Annexin-A5 assembled into two-dimensional arrays promotes cell membrane repair
This work shows that annexin-A5 (AnxA5), a protein that self-assembles into two-dimensional arrays on membranes upon Ca2+ activation, promotes membrane repair and participates in a previously unrecognized step of the membrane repair process.
Crystal structure of grape dihydroflavonol 4-reductase, a key enzyme in flavonoid biosynthesis.
Structure and epimerase activity of anthocyanidin reductase from Vitis vinifera.
- M. Gargouri, C. Manigand, B. Gallois
- Chemistry, MedicineActa Crystallographica Section D: Biological…
- 1 September 2009
The first three-dimensional structure of ANR is described at a resolution of 2.2 A and explains the inactivity of the enzyme in the presence of high salt concentrations.
Crystal structure and catalytic mechanism of leucoanthocyanidin reductase from Vitis vinifera.
A single amino acid change within the R2 domain of the VvMYB5b transcription factor modulates affinity for protein partners and target promoters selectivity
The findings indicate that VvMYB5bL is still able to bind DNA but the structural consequences linked to the mutation affect the capacity of the protein to activate the transcription of some flavonoid genes by modifying the interaction with its co-partner(s).
Microstructure, hardness and toughness of nanostructured and conventional WC-Co composites
Protein crystallography under xenon and nitrous oxide pressure: comparison with in vivo pharmacology studies and implications for the mechanism of inhaled anesthetic action.
It is proposed that alterations of cytosolic globular protein functions by general anesthetics would be responsible for the early stages of anesthesia such as amnesia and hypnosis and that additional alterations of ion-channel membrane receptor functions are required for deeper effects that progress to "surgical" anesthesia.
Remarkable ability of horse spleen apoferritin to demetallate hemin and to metallate protoporphyrin IX as a function of pH.
A mechanism is proposed to explain demetallation of heme, involving attack on the tetrapyrrole nitrogens of the protoporphyrin IX-Fe by protons derived from protein carboxylic acid groups and subsequent complexation of the iron by the corresponding carboxylates.
Binding-equilibrium and kinetic studies of anthocyanidin reductase from Vitis vinifera.
The epimerase activity of anthocyanidin reductase from Vitis vinifera and its regiospecific hydride transfers
It was found that deuterium was always incorporated at C2 and C4, and it was concluded that C3-epimerization should be achieved by tautomerization between the two hydride transfers and that this produces a quinone methide intermediate which serves as C4 target of the secondhydride transfer, thereby avoiding any stereospecific modification of carbon 3.