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Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime?
The properties and putative relationship of these two amino acid exchangers are discussed in the context of their demonstrated utility in cancer biology, including cellular growth and survival signaling and integrated links to the mammalian target-of-rapamycin (mTOR) kinase. Expand
Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis.
The EGF gene polymorphism genotype is associated with risk for development of hepatocellular carcinoma in liver cirrhosis through modulation of EGF levels through inhibition fragment-length polymorphism. Expand
Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma
Data suggest that EGFR inhibition using Food and Drug Administration‐approved inhibitors provides a promising therapeutic approach for reduction of fibrogenesis and prevention of HCC in high‐risk cirrhosis patients who can be identified and monitored by gene expression signatures. Expand
Epithelial-to-mesenchymal transition and integrin-linked kinase mediate sensitivity to epidermal growth factor receptor inhibition in human hepatoma cells.
It is suggested that epithelial-to-mesenchymal transition predicts HCC sensitivity to EGFR-targeted therapies and that ILK is a novel target to overcome HCC resistance to EG FR inhibition. Expand
miR-675 Mediates Downregulation of Twist1 and Rb in AFP-Secreting Hepatocellular Carcinoma
Expression of the miR-675 in hepatocellular carcinoma links a dramatic upregulation of proliferative and growth capacity with inhibition of motility in HCC cells. Expand
A functional polymorphism in the epidermal growth factor gene is associated with risk for hepatocellular carcinoma.
The EGF genotype G/G is associated with increased risk for HCC; differences in its frequency among black and white subjects might account for differences in HCC incidence between these groups. Expand
ASCT2 silencing regulates mammalian target-of-rapamycin growth and survival signaling in human hepatoma cells.
- B. Fuchs, R. Finger, Marie C. Onan, B. Bode
- Biology, Medicine
- American journal of physiology. Cell physiology
- 1 July 2007
The results suggest that ASCT2 silencing inhibits mTORC1 signaling to the translational machinery followed by an m TORC2-initiated survival response, establishing a link between amino acid transporter expression and mTOR function. Expand
Pathogenesis and prevention of hepatitis C virus-induced hepatocellular carcinoma.
Genome-wide, unbiased molecular characterization, high-throughput drug/gene screening, experimental model-based functional analysis, and systems-level in silico modelling are expected to complement each other to facilitate discovery of new HCC chemoprevention targets and therapies. Expand
Epithelial‐to‐mesenchymal transition predicts prognosis in clinical gastric cancer
Epithelial‐to‐mesenchymal transition (EMT) is considered to play an important role in cancer invasion and metastasis.
Mouse model of carbon tetrachloride induced liver fibrosis: Histopathological changes and expression of CD133 and epidermal growth factor
Species-specific differences exist with respect to the histopathological and molecular pathogenesis of chronic liver disease and CCl4-induced chronic liver injury in A/J mice has important differences compared to human cirrhosis leading to HCC. Expand