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Permeability of Endothelial and Astrocyte Cocultures: In Vitro Blood–Brain Barrier Models for Drug Delivery Studies
- Guanglei Li, M. J. Simon, +5 authors B. Fu
- Chemistry, Medicine
- Annals of Biomedical Engineering
- 2 April 2010
The blood–brain barrier (BBB) is a major obstacle for drug delivery to the brain. To seek for in vitro BBB models that are more accessible than animals for investigating drug transport across the… Expand
Mechano-sensing and transduction by endothelial surface glycocalyx: composition, structure, and function.
The endothelial cells (ECs) lining every blood vessel wall are constantly exposed to the mechanical forces generated by blood flow. The EC responses to these hemodynamic forces play a critical role… Expand
Acute VEGF effect on solute permeability of mammalian microvessels in vivo.
To investigate the effect of vascular endothelial growth factor (VEGF) on solute permeability of mammalian microvessels, we measured the apparent permeability (P) of various-sized solutes on the… Expand
The Structural Stability of the Endothelial Glycocalyx after Enzymatic Removal of Glycosaminoglycans
Rationale It is widely believed that glycosaminoglycans (GAGs) and bound plasma proteins form an interconnected gel-like structure on the surface of endothelial cells (the endothelial glycocalyx… Expand
Non-invasive measurement of solute permeability in cerebral microvessels of the rat.
To quantify the solute permeability of rat cerebral microvessels, we measured the apparent permeability (P) of pial microvessels to various sized solutes. The pial microcirculation was observed by a… Expand
Adhesion of malignant mammary tumor cells MDA-MB-231 to microvessel wall increases microvascular permeability via degradation of endothelial surface glycocalyx.
- B. Cai, J. Fan, M. Zeng, L. Zhang, B. Fu
- Chemistry, Medicine
- Journal of applied physiology
- 1 October 2012
To investigate the effect of tumor cell adhesion on microvascular permeability (P) in intact microvessels, we measured the adhesion rate of human mammary carcinoma MDA-MB-231, the hydraulic… Expand
Blood flow and permeability in microvessels
The mechanics of blood flow in microvessels and microvessel permeability are reviewed. In the first part, characteristics of blood flow in vivo and in vitro are described from a fluid-mechanical… Expand
Blood flow and permeability in microvessels (ナノ・サブマイクロ技術を用いた模擬/人工生体組織の創製と新診断・治療法の開発プロジェクト)
Quantification of blood-brain barrier solute permeability and brain transport by multiphoton microscopy.
- Lingyan Shi, M. Zeng, Y. Sun, B. Fu
- Medicine, Engineering
- Journal of biomechanical engineering
- 1 March 2014
Development of an optimal systemic drug delivery strategy to the brain will require noninvasive or minimally invasive methods to quantify the permeability of the cerebral microvessel wall or… Expand
A junction-orifice-fiber entrance layer model for capillary permeability: application to frog mesenteric capillaries.
The recent serial section electron microscopic studies by Adamson and Michel (1993) on microves gels of frog mesentery have revealed that the large pores in the junction strand of the… Expand