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Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity.
Severe and prolonged impairment of mitochondrial beta-oxidation leads to microvesicular steatosis, and, in severe forms, to liver failure, coma and death. Impairment of mitochondrial beta-oxidation… Expand
Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease
The worldwide epidemic of obesity and insulin resistance favors nonalcoholic fatty liver disease (NAFLD). Insulin resistance (IR) in the adipose tissue increases lipolysis and the entry of… Expand
Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver.
- K. Begriche, J. Massart, M. Robin, A. Borgne-Sanchez, B. Fromenty
- Biology, Medicine
- Journal of hepatology
- 1 April 2011
Numerous investigations have shown that mitochondrial dysfunction is a major mechanism of drug-induced liver injury, which involves the parent drug or a reactive metabolite generated through… Expand
NASH: a mitochondrial disease.
Despite our tendency to overeat, excessive fat accumulation was prevented in the past, as any excess weight soon impaired the physical fitness required to gather food, and to either fight or escape… Expand
Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it.
Calorie-enriched diet and lack of exercise are causing a worldwide surge of obesity, insulin resistance and lipid accretion in liver (i.e. hepatic steatosis), which can lead to steatohepatitis.… Expand
Mitochondria in steatohepatitis.
For the first time in history, populations in affluent countries may concomitantly indulge in rich food and physical idleness. Various combinations of obesity, diabetes, and hypertriglyceridemia,… Expand
Drug‐induced liver injury through mitochondrial dysfunction: mechanisms and detection during preclinical safety studies
Mitochondrial dysfunction is a major mechanism whereby drugs can induce liver injury and other serious side effects such as lactic acidosis and rhabdomyolysis in some patients. By severely altering… Expand
Nonalcoholic steatosis and steatohepatitis. V. Mitochondrial dysfunction in steatohepatitis.
- D. Pessayre, A. Mansouri, B. Fromenty
- Biology, Medicine
- American journal of physiology. Gastrointestinal…
- 1 February 2002
Rich diet and lack of exercise are causing a surge in the prevalence of obesity and hepatic steatosis, which causes "primary" steatohepatitis in some patients. Ultrastructural mitochondrial lesions,… Expand
Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: mechanisms and pathophysiological role.
- J. Aubert, K. Begriche, L. Knockaert, M.A. Robin, B. Fromenty
- Medicine, Biology
- Clinics and research in hepatology and…
- 1 October 2011
Due to the worldwide surge in obesity and type 2 diabetes, the increased incidence of nonalcoholic fatty liver disease (NAFLD) is a major concern for the public health. Indeed, NAFLD encompasses a… Expand
The ins and outs of mitochondrial dysfunction in NASH.
- B. Fromenty, M. Robin, A. Igoudjil, A. Mansouri, D. Pessayre
- Biology, Political Science
- Diabetes & metabolism
- 1 April 2004
Rich diet and lack of exercise are causing a surge in obesity, insulin resistance and steatosis, which can evolve into steatohepatitis. Steatosis and nonalcoholic steatohepatitis (NASH) can also be… Expand