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Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development.
Neuropilin-1 (Npn-1) is a receptor that binds multiple ligands from structurally distinct families, including secreted semaphorins (Sema) and vascular endothelial growth factors (VEGF). We generatedExpand
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Smaller inner ear sensory epithelia in Neurog1 null mice are related to earlier hair cell cycle exit
We investigated whether co‐expression of Neurog1 and Atoh1 in common neurosensory precursors could explain the loss of hair cells in Neurog1 null mice. Analysis of terminal mitosis, using BrdU,Expand
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Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea
Sox2 is a high-mobility transcription factor that is one of the earliest markers of developing inner ear prosensory domains. In humans, mutations in SOX2 cause sensorineural hearing loss and a lossExpand
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Transcription factor GATA‐3 alters pathway selection of olivocochlear neurons and affects morphogenesis of the ear
Patterning the vertebrate ear requires the coordinated expression of genes that are involved in morphogenesis, neurogenesis, and hair cell formation. The zinc finger gene GATA‐3 is expressed both inExpand
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Proprioceptor Pathway Development Is Dependent on MATH1
The proprioceptive system provides continuous positional information on the limbs and body to the thalamus, cortex, pontine nucleus, and cerebellum. We showed previously that the basicExpand
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Auditory system development: primary auditory neurons and their targets.
The neurons of the cochlear ganglion transmit acoustic information between the inner ear and the brain. These placodally derived neurons must produce a topographically precise pattern of connectionsExpand
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Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution
Lampreys are representatives of an ancient vertebrate lineage that diverged from our own ∼500 million years ago. By virtue of this deeply shared ancestry, the sea lamprey (P. marinus) genome isExpand
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FGF/FGFR-2(IIIb) Signaling Is Essential for Inner Ear Morphogenesis
Interactions between FGF10 and the IIIb isoform of FGFR-2 appear to be crucial for the induction and growth of several organs, particularly those that involve budding morphogenesis. We determinedExpand
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Expression and function of FGF10 in mammalian inner ear development
We have investigated the expression of FGF10 during ear development and the effect of an FGF10 null mutation on ear development. Our in situ hybridization data reveal expression of FGF10 in all threeExpand
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Spatial Shaping of Cochlear Innervation by Temporally Regulated Neurotrophin Expression
Previous work suggested qualitatively different effects of neurotrophin 3 (NT-3) in cochlear innervation patterning in different null mutants. We now show that allNT-3 null mutants have a similarExpand
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