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Arginine Vasopressin in Advanced Vasodilatory Shock: A Prospective, Randomized, Controlled Study
Background—Vasodilatory shock is a potentially lethal complication of severe disease in critically ill patients. Currently, catecholamines are the most widely used vasopressor agents to support blood… Expand
Microvascular and tissue oxygen gradients in the rat mesentery.
- A. Tsai, B. Friesenecker, +4 authors M. Intaglietta
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 9 June 1998
One of the most important functions of the blood circulation is O2 delivery to the tissue. This process occurs primarily in microvessels that also regulate blood flow and are the site of many… Expand
Plasma viscosity regulates capillary perfusion during extreme hemodilution in hamster skinfold model.
- A. Tsai, B. Friesenecker, M. McCarthy, H. Sakai, M. Intaglietta
- Medicine, Biology
- American journal of physiology. Heart and…
- 1 December 1998
Effect of increasing blood viscosity during extreme hemodilution on capillary perfusion and tissue oxygenation was investigated in the awake hamster skinfold model. Two isovolemic hemodilution steps… Expand
Reversal of trauma-induced coagulopathy using first-line coagulation factor concentrates or fresh frozen plasma (RETIC): a single-centre, parallel-group, open-label, randomised trial.
BACKGROUND Effective treatment of trauma-induced coagulopathy is important; however, the optimal therapy is still not known. We aimed to compare the efficacy of first-line therapy using fresh frozen… Expand
The Effect of Fibrinogen Substitution on Reversal of Dilutional Coagulopathy: An In Vitro Model
Colloids and crystalloids are usually administered as treatment for hypovolemia in severely injured patients. However, dilution of clotting factors and platelets together with impaired fibrinogen… Expand
Capillary perfusion during ischemia-reperfusion in subcutaneous connective tissue and skin muscle.
Ischemia-reperfusion injury was investigated in terms of functional capillary density (FCD), capillary red blood cell velocity (cRBCv), and arteriolar and venular diameter after 4-h ischemia in the… Expand
The Effects of Progressive Anemia on Jejunal Mucosal and Serosal Tissue Oxygenation in Pigs
Anemia may promote intestinal hypoxia.We studied the effects of progressive isovolemic hemodilution on jejunal mucosal (PO2 muc), and serosal tissue oxygen tension (PO2 ser, Clark-type surface… Expand
Central Venous Catheter Colonization in Critically Ill Patients: A Prospective, Randomized, Controlled Study Comparing Standard with Two Antiseptic-Impregnated Catheters
In this prospective, randomized, controlled, unblinded study, we compared colonization rates of a standard, unimpregnated central venous catheter (CVC) with rates for silver-coated and… Expand
Vasomotion induces regular major oscillations in jejunal mucosal tissue oxygenation.
- W. Hasibeder, R. Germann, +7 authors O. Ennemoser
- Biology, Medicine
- The American journal of physiology
- 1 June 1994
The mucosa of the small intestine has some unique microcirculatory features that may result in significant tissue oxygenation changes even under physiological conditions. To prove this hypothesis we… Expand
Capillary flow impairment and functional capillary density.
- A. Tsai, B. Friesenecker, M. Intaglietta
- International journal of microcirculation…
- 1 September 1995
Functional capillary density is variable in both normal and diseased tissue. When this parameter is defined as the number of capillaries that possess red blood cell transit, changes in functional… Expand