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- Publications
- Influence
Clustering by Passing Messages Between Data Points
TLDR
Factor graphs and the sum-product algorithm
- F. Kschischang, B. Frey, Hans-Andrea Loeliger
- Computer Science
- IEEE Trans. Inf. Theory
- 1 February 2001
TLDR
Predicting the sequence specificities of DNA- and RNA-binding proteins by deep learning
- B. Alipanahi, Andrew Delong, Matthew T. Weirauch, B. Frey
- Biology, Medicine
- Nature Biotechnology
- 1 August 2015
Knowing the sequence specificities of DNA- and RNA-binding proteins is essential for developing models of the regulatory processes in biological systems and for identifying causal disease variants.… Expand
A compendium of RNA-binding motifs for decoding gene regulation
TLDR
Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
- Q. Pan, Ofer Shai, L. Lee, B. Frey, B. Blencowe
- Biology, Medicine
- Nature Genetics
- 2 November 2008
We carried out the first analysis of alternative splicing complexity in human tissues using mRNA-Seq data. New splice junctions were detected in ∼20% of multiexon genes, many of which are tissue… Expand
Widespread intron retention in mammals functionally tunes transcriptomes.
- Ulrich Braunschweig, N. Barbosa-Morais, +6 authors B. Blencowe
- Biology, Medicine
- Genome research
- 1 November 2014
Alternative splicing (AS) of precursor RNAs is responsible for greatly expanding the regulatory and functional capacity of eukaryotic genomes. Of the different classes of AS, intron retention (IR) is… Expand
The human splicing code reveals new insights into the genetic determinants of disease
- H. Y. Xiong, B. Alipanahi, +14 authors B. Frey
- Biology, Medicine
- Science
- 9 January 2015
Predicting defects in RNA splicing Most eukaryotic messenger RNAs (mRNAs) are spliced to remove introns. Splicing generates uninterrupted open reading frames that can be translated into proteins.… Expand
The "wake-sleep" algorithm for unsupervised neural networks.
- G. E. Hinton, P. Dayan, B. Frey, R. Neal
- Computer Science, Medicine
- Science
- 26 May 1995
TLDR
The Evolutionary Landscape of Alternative Splicing in Vertebrate Species
- N. Barbosa-Morais, M. Irimia, +14 authors B. Blencowe
- Biology, Medicine
- Science
- 21 December 2012
Whence Species Variation? Vertebrates have widely varying phenotypes that are at odds with their much more limited proteincoding genotypes and conserved messenger RNA expression patterns. Genes with… Expand
Graphical Models for Machine Learning and Digital Communication
- B. Frey
- Computer Science
- 26 June 1998
TLDR