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Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
The cAMP-responsive element-binding protein (CREB) has been implicated in the activation of protein synthesis required for long-term facilitation, a cellular model of memory in Aplysia. Our studiesExpand
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Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase.
The AMP-activated protein kinase (AMPK) is a critical regulator of energy balance at both the cellular and whole-body levels. Two upstream kinases have been reported to activate AMPK in cell-freeExpand
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Mitochondrial Membrane Potential and Glutamate Excitotoxicity in Cultured Cerebellar Granule Cells
The relationship between changes in mitochondrial membrane potential (Δψm) and the failure of cytoplasmic Ca2+ homeostasis, delayed Ca2+deregulation (DCD), is investigated for cultured rat cerebellarExpand
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Temporal and mechanistic dissociation of ATP and adenosine release during ischaemia in the mammalian hippocampus1
Adenosine is well known to be released during cerebral metabolic stress and is believed to be neuroprotective. ATP release under similar circumstances has been much less studied. We have now usedExpand
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Direct measurement of adenosine release during hypoxia in the CA1 region of the rat hippocampal slice
1 We have used an enzyme‐based, twin‐barrelled sensor to measure adenosine release during hypoxia in the CA1 region of rat hippocampal slices in conjunction with simultaneous extracellular fieldExpand
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Synaptic Tagging and Capture: Differential Role of Distinct Calcium/Calmodulin Kinases in Protein Synthesis-Dependent Long-Term Potentiation
Weakly tetanized synapses in area CA1 of the hippocampus that ordinarily display long-term potentiation lasting ∼3 h (called early-LTP) will maintain a longer-lasting change in efficacy (late-LTP) ifExpand
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Dopaminergic modulation of the persistence of one-trial hippocampus-dependent memory.
The persistence of new memory traces in the hippocampus, encoded following appropriate activation of glutamatergic receptors and the induction of synaptic plasticity, can be influenced byExpand
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Adenosine and ATP Link PCO2 to Cortical Excitability via pH
In addition to affecting respiration and vascular tone, deviations from normal CO(2) alter pH, consciousness, and seizure propensity. Outside the brainstem, however, the mechanisms by which CO(2)Expand
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miR-132/212 Knockout Mice Reveal Roles for These miRNAs in Regulating Cortical Synaptic Transmission and Plasticity
miR-132 and miR-212 are two closely related miRNAs encoded in the same intron of a small non-coding gene, which have been suggested to play roles in both immune and neuronal function. We describeExpand
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Characterization of Ca2+ signals induced in hippocampal CA1 neurones by the synaptic activation of NMDA receptors.
1. A combination of confocal microscopy, whole‐cell patch‐clamp recording, intracellular dialysis and pharmacological techniques have been employed to study Ca2+ signalling in CA1 pyramidal neurones,Expand
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