• Publications
  • Influence
Anthocyanins, phenolics, and antioxidant capacity in diverse small fruits: vaccinium, rubus, and ribes.
TLDR
Though ACY may indicate TPH, the range observed in ACY/TPH ratios precludes prediction of ACY from TPH and vice versa for a single genotype, and in general, TPH was more highly correlated to antioxidant capacity than ACY was. Expand
Ascorbate is an outstanding antioxidant in human blood plasma.
TLDR
The data demonstrate that ascorbate is the most effective aqueous-phase antioxidant in human blood plasma and suggest that in humans ascorBate is a physiological antioxidant of major importance for protection against diseases and degenerative processes caused by oxidant stress. Expand
Coffee and Health: A Review of Recent Human Research
  • J. Higdon, B. Frei
  • Medicine
  • Critical reviews in food science and nutrition
  • 1 March 2006
TLDR
Current available evidence suggests that it may be prudent for pregnant women to limit coffee consumption to 3 cups/d providing no more than 300 mg/d of caffeine to exclude any increased probability of spontaneous abortion or impaired fetal growth, and there is little evidence that coffee consumption increases the risk of cancer. Expand
Antioxidants and atherosclerotic heart disease.
TLDR
There is evidence that plaque stability, vasomotor function, and the tendency to thrombosis are subject to modification by specific antioxidants, and it is speculated that these mechanisms have an important role in the benefits of antioxidants. Expand
Does vitamin C act as a pro‐oxidant under physiological conditions?
  • A. Carr, B. Frei
  • Medicine, Biology
  • FASEB journal : official publication of the…
  • 1 June 1999
TLDR
Although the data on protein oxidation in humans are sparse and inconclusive, the available data in animals consistently show an antioxidant role of vitamin C, both in the presence and absence of metal ions. Expand
A new proposed guidance system for beverage consumption in the United States.
TLDR
The panel ranked beverages from the lowest to the highest value based on caloric and nutrient contents and related health benefits and risks, and recommended that the consumption of beverages with no or few calories should take precedence over the consumptionof beverages with more calories. Expand
Tea Catechins and Polyphenols: Health Effects, Metabolism, and Antioxidant Functions
  • J. Higdon, B. Frei
  • Chemistry, Medicine
  • Critical reviews in food science and nutrition
  • 1 January 2003
TLDR
The effects of tea and green tea catechins on biomarker of oxidative stress, especially oxidative DNA damage, appear very promising in animal models, but data on biomarkers of in vivo oxidative stress in humans are limited. Expand
Antioxidant activity of tea polyphenols in vivo: evidence from animal studies.
TLDR
Most promising are the consistent findings in animal models of skin, lung, colon, liver and pancreatic cancer that tea and tea polyphenol administration inhibit carcinogen-induced increases in the oxidized DNA base, 8-hydroxy-2'-deoxyguanosine. Expand
Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: cause, consequence, or epiphenomenon?
  • S. Lotito, B. Frei
  • Chemistry, Medicine
  • Free radical biology & medicine
  • 15 December 2006
TLDR
It is concluded that the large increase in plasma total antioxidant capacity observed after the consumption of flavonoid-rich foods is not caused by the flavonoids themselves, but is likely the consequence of increased uric acid levels. Expand
Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans.
  • A. Carr, B. Frei
  • Medicine
  • The American journal of clinical nutrition
  • 1 June 1999
TLDR
The totality of the reviewed data suggests that an intake of 90-100 mg vitamin C/d is required for optimum reduction of chronic disease risk in nonsmoking men and women, suggesting a new RDA of 120 mg vitaminC/d. Expand
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