Skip to search formSkip to main contentSkip to account menu
Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.
TLDR
It is proposed that superoxide dismutase may protect vascular tissue stimulated to produce superoxide and NO under pathological conditions by preventing the formation of peroxynitrite.
View on Publisher
Biology of disease: free radicals and tissue injury.
  • B. Freeman, J. Crapo
  • Chemistry, Biology
    Laboratory investigation; a journal of technical…
  • 1 November 1982
TLDR
This review surveys cellular sources of free radicals and the reactions they can undergo and discusses cellular defenses and adaptive mechanisms.
View on PubMed
Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.
TLDR
Forms of hypertension associated with elevated circulating levels of angiotensin II may have unique vascular effects not shared by other forms of hypertension because they increase vascular smooth muscle .O2- production via NADH/NADPH oxidase activation.
View on PubMed
Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
TLDR
The data reveal that NO2− may regulate inflammatory processes through oxidative mechanisms, perhaps by contributing to the tyrosine nitration and chlorination observed in vivo.
View on Springer
Endothelial Regulation of Vasomotion in ApoE-Deficient Mice: Implications for Interactions Between Peroxynitrite and Tetrahydrobiopterin
TLDR
Reactive oxygen species may alter endothelium-dependent vascular relaxation not only by the interaction of O2·− with NO· but also through interactions between peroxynitrite and tetrahydrobiopterin.
View on Wolters Kluwer
Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide.
View on PubMed
Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance.
TLDR
It is shown that continuous NTG treatment is associated with increased vascular .-O2-production and consequent inhibition of NO and mediated vasorelaxation produced by both exogenous and endogenous nitrovasodilators.
View on PubMed
Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide.
View on PubMed
Role of superoxide in angiotensin II-induced but not catecholamine-induced hypertension.
TLDR
Hypertension caused by chronically elevated angiotensin II is mediated in part by .O2-, likely via degradation of endothelium-derived NO, and may contribute to vascular disease in high renin/angiotens in II states.
View on PubMed
Detection of catalase in rat heart mitochondria.
View on PubMed
...
...
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License