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International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors.
TLDR
Experiments with receptor antagonists and mice with targeted disruption of adenosine A(1), A(2A), and A(3) expression reveal roles for these receptors under physiological and particularly pathophysiological conditions. Expand
Abolished tubuloglomerular feedback and increased plasma renin in adenosine A1 receptor-deficient mice.
TLDR
It is demonstrated that adenosine acting on A1R is required for TGF and modulates renin release. Expand
Pharmacology of adenosine A2A receptors.
TLDR
In this review, Ennio Ongini and Bertil Fredholm describe how recently developed potent and selective A2A receptor antagonists can be used to delineate the physiological and pathological processes regulated by A 2A receptors. Expand
Differences in the regional and cellular localization of c-fos messenger RNA induced by amphetamine, cocaine and caffeine in the rat
TLDR
Each of the different CNS stimulant drugs induces a highly specific pattern of c-fos messenger RNA, which is concluded to be similar to that experienced with amphetamine and cocaine. Expand
Adenosine receptor ligands: differences with acute versus chronic treatment.
TLDR
A complication to the therapeutic use of adenosine receptor ligands is the observation that the effects of acute administration of a particular ligand can be diametrically opposite to the chronic effects of the same ligand. Expand
Long‐term Treatment with some Methylxanthines Decreases the Susceptibility to Bicuculline‐ and Pentylenetetrazol‐induced Seizures in Mice. Relationship to c‐ios Expression and Receptor Binding
TLDR
Results show that long‐term treatment with caffeine in a dose that is commonly seen in humans decreases the seizures induced by bicuculline, and to a lesser extent, those induced by PTZ. Expand
The binding of the adenosine A2 receptor selective agonist [3H]CGS 21680 to rat cortex differs from its binding to rat striatum.
TLDR
The present results show that there is a cortical binding site for [3H]CGS 21680 which appears to be different from the the striatal A2A receptor, the A2B receptor and the A1 receptor. Expand
Release of endogenous and radioactive purines from the rabbit retina
TLDR
It is concluded that there is an intensive uptake and phosphorylation of adenosine in the rabbit retina and the release of radioactive purines may be released in the form of nucleosides. Expand
Further characterization of the binding of the adenosine receptor agonist [3H]CGS 21680 to rat brain using autoradiography
TLDR
Evidence is provided that in cerebral cortex and hippocampus, most of the [3H]CGS 21680 binds to a receptor site that is distinct from the striatal A2A receptor and the classical adenosine A1 receptor and may represent a hitherto unrecognized binding site. Expand
Distribution and postnatal ontogeny of adenosine A2A receptors in rat brain: comparison with dopamine receptors
TLDR
Postnatal changes in adenosine receptors may explain age-dependent differences in stimulatory caffeine effects and endogenous protection against seizures, since A2A receptors show a co-distribution with D2 receptors throughout development, caffeine may partly exert such actions by regulating the activity of D2 receptor-containing striatopallidal neurons. Expand
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