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Encoding, consolidation, and retrieval of contextual memory: differential involvement of dorsal CA3 and CA1 hippocampal subregions.
Findings point as evidence that CA1 and CA3 subregions of the dorsal hippocampus play important and different roles in the acquisition and consolidation of contextual fear memory, whereas they are not required for context recognition. Expand
Protein degradation, as with protein synthesis, is required during not only long‐term spatial memory consolidation but also reconsolidation
- J. Artinian, A. T. McGauran, X. de Jaeger, L. Moulédous, B. Francés, P. Roullet
- Psychology, Medicine
- The European journal of neuroscience
- 1 June 2008
It is suggested that protein degradation is a key step for memory reconsolidation, as for consolidation, as the results show that, in the CA3 hippocampal region, consolidation of an allocentric spatial learning task requires two waves of protein synthesis taking place immediately and 4 h after acquisition, whereas reconsolidations requires only the first wave. Expand
Further evidence that morphine-6 beta-glucuronide is a more potent opioid agonist than morphine.
- B. Francés, R. Gout, B. Monsarrat, J. Cros, J. Zajac
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 July 1992
In vivo binding studies showed that M6G exerts its antinociceptive effect at low (less than 1%) fractional occupancy of [3H]diprenorphine-specific binding sites, which appears to have greater pharmacological potency than morphine, which in comparison possesses a low intrinsic efficacy. Expand
Characterization of the binding of a potent, selective, radioiodinated antagonist to the human neurokinin-1 receptor.
The data suggest that the pharmacological properties of [125I]L-703606 binding to the human NK1 receptor are similar to those of antagonists of nonpeptide guanine nucleotide-binding protein-coupled receptors and that this ligand will be useful for the biochemical and pharmacological characterization of the humanNK1 receptor. Expand
Further Evidence that Morphine-6-Glucuronide is a More Patent Opioid Agonist than Morphine
Age-dependent increase in hydrogen peroxide production by cardiac monoamine oxidase A in rats.
- A. Maurel, C. Hernandez, +4 authors B. Francés
- Biology, Medicine
- American journal of physiology. Heart and…
- 1 April 2003
The results suggest that MAO-A could be a major source of H( 2)O(2) in the aging heart. Expand
Solubilization of two molecular forms of the frog brain opioid receptor
Preliminary evidence is given that in extracts of frog brain membranes which have been pre-incubated with 120 mM NaCl, the balance of the two components is shifted in favor of the slower sedimenting (10S) one. Expand
A neuropeptide FF agonist blocks the acquisition of conditioned place preference to morphine in C57Bl/6J mice
It is suggested that neuropeptide FF, injected during conditioning, should influence the development of rewarding effects of morphine and reinforce the hypothesis of strong inhibitory interactions between neuropePTide FF and opioids. Expand
Effects of ibogaine on naloxone‐precipitated withdrawal in morphine‐dependent mice
While acute antinociceptive effects of morphine are modulated by ibogaine, this drug, shown to alleviate opiate dependence in man, does not attenuate in mice opioid withdrawal manifestations. Expand
Transient activation of the CA3 Kappa opioid system in the dorsal hippocampus modulates complex memory processing in mice
- S. Daumas, A. Bétourné, +4 authors B. Francés
- Psychology, Medicine
- Neurobiology of Learning and Memory
- 1 July 2007
In the mouse, even partial and topographically restricted activation of CA3-KOR entails impairments in two different hippocampus-dependent tasks, indicating functional relevance of the kappa opioid system. Expand