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Use of high-throughput RT-qPCR to assess modulations of gene expression profiles related to genomic stability and interactions by cadmium
The Fluidigm dynamic array on the BioMark™ HD System for quantitative high-throughput RT-qPCR analysis of 95 genes and 96 samples in parallel, selecting genes crucial for maintaining genomic stability, including stress response as well as DNA repair, cell cycle control, apoptosis and mitotic signaling, revealed distinct dose- and time-dependent and cell-type-specific gene expression patterns.
The in vitro PIG-A gene mutation assay: glycosylphosphatidylinositol (GPI)-related genotype-to-phenotype relationship in TK6 cells
This work investigated the GPI-related genotype-to-phenotype relationship in TK6 cells and identified a heterozygous chromosomal deletion on chromosome 17, where the PIG-L gene is located, which could be responsible for the increased sensitivity toward mutagenic ethyl methanesulfonate or UV-C treatments of p53-proficient TK8 cells.
Single nucleotide polymorphisms in DNA repair genes and putative cancer risk
The present review describes some of the common and most extensively studied SNPs in DNA repair genes and discusses whether they are functionally relevant and subsequently increase the likelihood that cancer will develop.