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Recent Advances in Understanding Enteric Pathogenic Escherichia coli
- Matthew A. Croxen, Robyn J Law, Roland Scholz, K. Keeney, M. Wlodarska, B. Finlay
- MedicineClinical Microbiology Reviews
- 1 October 2013
A comprehensive review highlights recent advances in understanding of the intestinal pathotypes of E. coli, which carry an enormous potential to cause disease and continue to present challenges to human health.
Enteropathogenic E. coli (EPEC) Transfers Its Receptor for Intimate Adherence into Mammalian Cells
Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine.
Dissecting virulence: systematic and functional analyses of a pathogenicity island.
- W. Deng, J. Puente, B. Finlay
- Biology, MedicineProceedings of the National Academy of Sciences…
- 9 March 2004
This work systematically mutagenized all 41 CR LEE genes and functionally characterized these mutants in vitro and in a murine infection model, identifying 33 virulence factors, including two virulence regulators and a hierarchical switch for type III secretion.
Molecular mechanisms of Escherichia coli pathogenicity
This Review focuses on the recent advances in the understanding of the different pathogenic mechanisms that are used by various E. coli pathovars and how they cause disease in humans.
Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells
It is shown that tyrosine 474 of Tir directly binds the host-cell adaptor protein Nck, and that Nck is required for the recruitment of both neural Wiskott–Aldrich-syndrome protein (N-WASP) and the actin-related protein (Arp)2/3 complex to the EPEC pedestal, directly linking Tir to the cytoskeleton.
Common themes in microbial pathogenicity revisited.
Comprehension of common themes in microbial pathogenicity is critical to the understanding and study of bacterial virulence mechanisms and to the development of new "anti-virulence" agents, which are so desperately needed to replace antibiotics.
Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae.
Identification of a Salmonella virulence gene required for formation of filamentous structures containing lysosomal membrane glycoproteins within epithelial cells
Salmonella species are facultative intracellular pathogens that invade epithelial cells and reside within lysosomal membrane glycoprotein (Igp)‐containing vacuoles, and they induce the formation of stable Igp‐containing filamentous structures that connect with the Salmonella‐containing Vacuoles.
The NRAMP proteins of Salmonella typhimurium and Escherichia coli are selective manganese transporters involved in the response to reactive oxygen
The cloning and characterization of the single NRAMP genes in Escherichia coli and Salmonella enterica ssp.