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Recent Advances in Understanding Enteric Pathogenic Escherichia coli
SUMMARY Although Escherichia coli can be an innocuous resident of the gastrointestinal tract, it also has the pathogenic capacity to cause significant diarrheal and extraintestinal diseases.Expand
Enteropathogenic E. coli (EPEC) Transfers Its Receptor for Intimate Adherence into Mammalian Cells
Enteropathogenic E. coli (EPEC) belongs to a group of bacterial pathogens that induce epithelial cell actin rearrangements resulting in pedestal formation beneath adherent bacteria. This requires theExpand
Dissecting virulence: systematic and functional analyses of a pathogenicity island.
Bacterial pathogenicity islands (PAI) often encode both effector molecules responsible for disease and secretion systems that deliver these effectors to host cells. Human enterohemorrhagicExpand
Salmonella, the host and disease: a brief review
Salmonella species cause substantial morbidity, mortality and burden of disease globally. Infections with Salmonella species cause multiple clinical syndromes. Central to the pathophysiology of allExpand
Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine.
The requirements for in vivo steady state differentiation of IL-17-producing T-helper (Th17) cells, which are potent inflammation effectors, remain obscure. We report that Th17 cell differentiationExpand
Molecular mechanisms of Escherichia coli pathogenicity
Escherichia coli is a remarkable and diverse organism. This normally harmless commensal needs only to acquire a combination of mobile genetic elements to become a highly adapted pathogen capable ofExpand
Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells
Enteropathogenic Escherichia coli (EPEC) is a bacterial pathogen that causes infantile diarrhea worldwide. EPEC injects a bacterial protein, translocated intimin receptor (Tir), into the host-cellExpand
Common themes in microbial pathogenicity revisited.
  • B. Finlay, S. Falkow
  • Biology, Medicine
  • Microbiology and molecular biology reviews : MMBR
  • 1 June 1997
Bacterial pathogens employ a number of genetic strategies to cause infection and, occasionally, disease in their hosts. Many of these virulence factors and their regulatory elements can be dividedExpand
Enterohemorrhagic Escherichia coliO157:H7 Produces Tir, Which Is Translocated to the Host Cell Membrane but Is Not Tyrosine Phosphorylated
ABSTRACT Intimate attachment to the host cell leading to the formation of attaching and effacing (A/E) lesions is an essential feature of enterohemorrhagic Escherichia coli (EHEC) O157:H7Expand
Identification of a Salmonella virulence gene required for formation of filamentous structures containing lysosomal membrane glycoproteins within epithelial cells
Salmonella species are facultative intracellular pathogens that invade epithelial cells and reside within lysosomal membrane glycoprotein (Igp)‐containing vacuoles. Coincident with the onset ofExpand