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Inflammation and Alzheimer’s disease
Minocycline, a Tetracycline Derivative, Is Neuroprotective against Excitotoxicity by Inhibiting Activation and Proliferation of Microglia
TLDR
The findings indicate that the proliferation and activation of microglia contributes to excitotoxicity, which is inhibited by minocycline, an antibiotic used in severe human infections.
The Serotoninergic Receptors of Human Dendritic Cells: Identification and Coupling to Cytokine Release 1
TLDR
The study shows that 5-HT stimulated, in a maturation-dependent manner, different signaling pathways in DC, pointing to a role for 5- HT in regulating the immune response at peripheral sites.
The neuropeptide substance P activates transcription factor NF-kappa B and kappa B-dependent gene expression in human astrocytoma cells.
TLDR
In U373 MG astrocytoma cells, nanomolar concentrations of substance P potently triggered activation of NF-kappa B, a transcription factor involved in the control of cytokine expression and apoptosis, and it is suggested that NF- kappa B may be an important component controlling neurogenic inflammation within the peripheral and central nervous system.
Caffeic Acid Phenethyl Ester Inhibits T-Cell Activation by Targeting Both Nuclear Factor of Activated T-Cells and NF-κB Transcription Factors
TLDR
The immunosuppressive activity of CAPE is evaluated in human T-cells, discovering that this phenolic compound is a potent inhibitor of early and late events in T-cell receptor-mediated T- cell activation.
The Neuropeptide Substance P Activates p38 Mitogen-Activated Protein Kinase Resulting in IL-6 Expression Independently from NF-κB1
Substance P (SP), a member of the tachykinin peptide family, is a major mediator of neuroimmunomodulatory activities and neurogenic inflammation within the central and peripheral nervous system. SP
Interferon alpha (IFNalpha) and psychiatric syndromes: a review.
TLDR
Research findings of neuropsychiatric syndromes induced by IFNalpha treatment, the putative mechanisms underlying those syndrome, and their treatment are reviewed and the question is addressed whether IFN alpha may contribute to the etiopathology of endogenous psychiatric disorders.
Caffeic acid phenethyl ester inhibits T-cell activation by targeting both nuclear factor of activated T-cells and NF-kappaB transcription factors.
TLDR
The immunosuppressive activity of CAPE is evaluated in human T-cells, discovering that this phenolic compound is a potent inhibitor of early and late events in T-cell receptor-mediated T- cell activation.
Cyclooxygenase‐2 expression in rat microglia is induced by adenosine A2a‐receptors
TLDR
The results strongly suggest that adenosine A2a‐receptor‐induced intracellular signaling events cause an up‐regulation of the COX‐2 gene and the release of PGE2, and that COX inhibitors may be of therapeutic benefit.
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