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Arabidopsis snc2-1D Activates Receptor-Like Protein-Mediated Immunity Transduced through WRKY70[C][W]
This work identifies a semidominant allele of an Arabidopsis conserved receptor-like protein that activates plant immunity and whose signal is transduced through the transcription factor WRKY70.Expand
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Ack1 Mediated AKT/PKB Tyrosine 176 Phosphorylation Regulates Its Activation
The AKT/PKB kinase is a key signaling component of one of the most frequently activated pathways in cancer and is a major target of cancer drug development. Most studies have focused on itsExpand
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A chemical and phosphoproteomic characterization of dasatinib action in lung cancer
We describe a strategy to comprehend signaling pathways active in lung cancer cells and targeted by dasatinib employing chemical proteomics to identify direct interacting proteins combined withExpand
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H2B Tyr37 phosphorylation suppresses expression of replication-dependent core histone genes
Histone gene transcription is actively downregulated after completion of DNA synthesis to avoid overproduction. However, the precise mechanistic details of the cessation of histone mRNA synthesis areExpand
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SIRT1 Negatively Regulates the Activities, Functions, and Protein Levels of hMOF and TIP60
ABSTRACT SIRT1 is a NAD+-dependent histone H4K16 deacetylase that controls several different normal physiologic and disease processes. Like most histone deacetylases, SIRT1 also deacetylatesExpand
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Tyrosine Phosphoproteomics Identifies Both Codrivers and Cotargeting Strategies for T790M-Related EGFR-TKI Resistance in Non–Small Cell Lung Cancer
Purpose: Irreversible EGFR-tyrosine kinase inhibitors (TKI) are thought to be one strategy to overcome EGFR-TKI resistance induced by T790M gatekeeper mutations in non–small cell lung cancer (NSCLC),Expand
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Structural and kinetic analysis of caspase-3 reveals role for s5 binding site in substrate recognition.
The molecular basis for the substrate specificity of human caspase-3 has been investigated using peptide analog inhibitors and substrates that vary at the P2, P3, and P5 positions. Crystal structuresExpand
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Identification of a binding motif specific to HNF4 by comparative analysis of multiple nuclear receptors
Nuclear receptors (NRs) regulate gene expression by binding specific DNA sequences consisting of AG[G/T]TCA or AGAACA half site motifs in a variety of configurations. However, thoseExpand
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HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSα.
MutS protein homolog 2 (MSH2) is a key DNA mismatch repair protein. It forms the MSH2-MSH6 (MutSα) and MSH2-MSH3 (MutSβ) heterodimers, which help to ensure genomic integrity. MutSα not onlyExpand
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Unification of de novo and acquired ibrutinib resistance in mantle cell lymphoma
The novel Bruton's tyrosine kinase inhibitor ibrutinib has demonstrated high response rates in B-cell lymphomas; however, a growing number of ibrutinib-treated patients relapse with resistance andExpand
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