B. F. King

Publications76
h-index37
Citations4,646
Highly Influential Citations321
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International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits.
TLDR
This review describes the structure, distribution, function, and ligand recognition characteristics of P2X receptors, which comprise seven distinct subunits that can function as both homo- and hetero- polymers. Expand
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Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family.
The cloning of a human G-protein-coupled receptor (GPCR) that specifically responds to UDP-glucose and related sugar-nucleotides has been reported recently. This receptor has important structural… Expand
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Molecular cloning and characterization of rat P2Y4 nucleotide receptor
An intronless open reading frame encoding a protein (361aa in length) was isolated from a rat genomic library probed with a DNA fragment from rat heart. This protein showed 83% sequence identity with… Expand
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Effects of extracellular pH on agonism and antagonism at a recombinant P2X2 receptor
Under voltage‐clamp conditions, the activity of agonists and antagonists at a recombinant P2X2 receptor expressed in Xenopus oocytes was examined at different levels of extracellular pH (pHe). In… Expand
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Full sensitivity of P2times2 purinoceptor to ATP revealed by changing extracellular pH
A full pharmacological characterization was carried out on a recombinant ATP‐gated ion channel (P2times2 purinoceptor) expressed in Xenopus oocytes. This slowly‐desensitizing neuronal P2times2… Expand
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Coexpression of Rat P2X2 and P2X6Subunits in Xenopus Oocytes
Transcripts for P2X2 and P2X6 subunits are present in rat CNS and frequently colocalize in the same brainstem nuclei. When rat P2X2 (rP2X2) and rat P2X6 (rP2X6) receptors were expressed individually… Expand
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Modulation of ATP‐responses at recombinant rP2X4 receptors by extracellular pH and zinc
The modulatory effects of extracellular H+ and Zn2+ were tested against ATP‐responses at rat P2X4 (rP2X4) receptors expressed in Xenopus oocytes under voltage‐clamp conditions. ATP (0.1–100 μM, at pH… Expand
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Modulatory activity of extracellular H+ and Zn2+ on ATP‐responses at rP2X1 and rP2X3 receptors
The modulatory activity of extracellular H+ and Zn2+ was examined on ATP‐responses at rat P2X1 (rP2X1) and rat P2X3 (rP2X3) receptors expressed in Xenopus oocytes and studied under voltage‐clamp… Expand
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Cloning and functional expression of a brain G‐protein‐coupled ATP receptor
A cDNA encoding a novel member of the G‐protein‐coupled receptor (GCR) superfamily, an ATP receptor, has been isolated from an embryonic chick whole brain cDNA library by hybridization screening. The… Expand
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Selectivity and activity of adenine dinucleotides at recombinant P2x2 and P2Y1 purinoceptors
1 Adenine dinucleotides (APxA, × = 2–6) are naturally‐occurring polyphosphated nucleotidic substances which are found in the CNS and are known to be released in a calcium‐dependent manner from… Expand
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