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Treatment with tin prevents the development of hypertension in spontaneously hypertensive rats.
TLDR
Treatment of young, spontaneously hypertensive rats with stannous chloride (SnCl2), which selectively depletes renal cytochrome P-450, restored BP to normal, coincident with a natriuresis, in young but not in adult SHRs and did not affect either BP or sodium excretion in WKYs. Expand
Effect of heme arginate administration on blood pressure in spontaneously hypertensive rats.
TLDR
It is postulated that heme arginate treatment resulted in induction of heme oxygenase which consequently led to a diminution of cytochrome P450, especially the arachidonate omega/omega-1 hydroxylases leading to a marked decrease in 19-hydroxyeicosatetraenoic acid (HETE) and 20-HETEs, both of which may promote hypertension by causing vasoconstriction and sodium retention. Expand
Effect of cytochrome P450 arachidonate metabolites on ion transport in rabbit kidney loop of Henle.
TLDR
Inhibition by cytochrome P450 blockade of the effect of AA on 86Rb uptake could be circumvented by addition of the principal products of AA metabolism in the mTALH. Expand
Metabolism of 20-hydroxyeicosatetraenoic acid by cyclooxygenase. Formation and identification of novel endothelium-dependent vasoconstrictor metabolites.
TLDR
The inhibitory effect of SQ29548, the appearance of labile metabolites with a half-life of approximately 6 min and the production of 20-hydroxy-PGF2 alpha by SnCl2 reduction clearly indicate that the vasoconstrictor metabolites of 21-HETE are the labile endoperoxides of 20, HETE, 20- Hydroxy-PGG2, and 20-Hydroxy- PGH2. Expand
Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve.
TLDR
It is suggested that endogenous eNOS-derived NO exerts direct effects in preserving blood flow, thereby promoting arteriogenesis, angiogenesis and mural cell recruitment to immature angiogenic sprouts. Expand
Pancreatic Insulin Secretion in Rats Fed a Soy Protein High Fat Diet Depends on the Interaction between the Amino Acid Pattern and Isoflavones*
TLDR
Isoflavones as well as the amino acid pattern seen after SP consumption stimulated insulin secretion to a lower extent, decreasing PPARγ, GLUT-2, and SREBP-1 expression, and ameliorating hyperinsulinemia observed during obesity. Expand
Antiinflammatory activity of extracts from Aloe vera gel.
TLDR
It is demonstrated that the extracts of Aloe vera gel have antiinflammatory activity and suggested its inhibitory action on the arachidonic acid pathway via cyclooxygenase. Expand
19(S)-hydroxyeicosatetraenoic acid is a potent stimulator of renal Na+-K+-ATPase.
TLDR
The formation of 19(S)-hydroxyeicosatetraenoic acid by renal cortical cytochrome P450 omega-1-hydroxylase may contribute to the regulation of renal function by regulating Na+-K+-ATPase which is essential for transtubular transport processes. Expand
Chronic Treatment With Tin Normalizes Blood Pressure in Spontaneously Hypertensive Rats
TLDR
It is reported that chronic treatment with SnCl2, begun at age 5 weeks, prevented the development of hypertension in SHR over a period of 15 weeks at which time they were killed, and found that age-matched WKY rats were not affected by tin treatment. Expand
Angiotensin II induces TNF production by the thick ascending limb: functional implications.
TLDR
It is concluded that angiotensin II regulates TNF production in the MTAL, an interaction that affects 86Rb uptake via an eicosanoid-dependent mechanism in this nephron segment. Expand
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