B. Eichman

Publications134
h-index26
Citations2,235
Highly Influential Citations147
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SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replication.
SMARCAL1 (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A-like1) maintains genome integrity during DNA replication. Here we investigated its mechanism of… Expand
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Structural basis for the dual coding potential of 8‐oxoguanosine by a high‐fidelity DNA polymerase
Accurate DNA replication involves polymerases with high nucleotide selectivity and proofreading activity. We show here why both fidelity mechanisms fail when normally accurate T7 DNA polymerase… Expand
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HLTF's Ancient HIRAN Domain Binds 3' DNA Ends to Drive Replication Fork Reversal.
Stalled replication forks are a critical problem for the cell because they can lead to complex genome rearrangements that underlie cell death and disease. Processes such as DNA damage tolerance and… Expand
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The Holliday junction in an inverted repeat DNA sequence: sequence effects on the structure of four-way junctions.
Holliday junctions are important structural intermediates in recombination, viral integration, and DNA repair. We present here the single-crystal structure of the inverted repeat sequence… Expand
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Substrate-selective repair and restart of replication forks by DNA translocases.
Stalled replication forks are sources of genetic instability. Multiple fork-remodeling enzymes are recruited to stalled forks, but how they work to promote fork restart is poorly understood. By… Expand
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Domain structure of the DEMETER 5-methylcytosine DNA glycosylase
DNA glycosylases initiate the base excision repair (BER) pathway by excising damaged, mismatched, or otherwise modified bases. Animals and plants independently evolved active BER-dependent DNA… Expand
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Physical Interactions between Mcm10, DNA, and DNA Polymerase α*
Mcm10 is an essential eukaryotic protein required for the initiation and elongation phases of chromosomal replication. Specifically, Mcm10 is required for the association of several replication… Expand
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Domain Architecture and Biochemical Characterization of Vertebrate Mcm10*
Mcm10 plays a key role in initiation and elongation of eukaryotic chromosomal DNA replication. As a first step to better understand the structure and function of vertebrate Mcm10, we have determined… Expand
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Structural basis for DNA binding by replication initiator Mcm10.
Mcm10 is an essential eukaryotic DNA replication protein required for assembly and progression of the replication fork. The highly conserved internal domain (Mcm10-ID) has been shown to physically… Expand
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Recent advances in the structural mechanisms of DNA glycosylases.
DNA glycosylases safeguard the genome by locating and excising a diverse array of aberrant nucleobases created from oxidation, alkylation, and deamination of DNA. Since the discovery 28years ago that… Expand
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