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- Publications
- Influence
SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replication.
- Rémy Bétous, A. C. Mason, +5 authors D. Cortez
- Biology, Medicine
- Genes & development
- 15 January 2012
SMARCAL1 (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A-like1) maintains genome integrity during DNA replication. Here we investigated its mechanism of… Expand
Structural basis for the dual coding potential of 8‐oxoguanosine by a high‐fidelity DNA polymerase
- L. G. Brieba, B. Eichman, R. Kokoska, S. Doublié, T. A. Kunkel, T. Ellenberger
- Physics, Medicine
- The EMBO journal
- 1 September 2004
Accurate DNA replication involves polymerases with high nucleotide selectivity and proofreading activity. We show here why both fidelity mechanisms fail when normally accurate T7 DNA polymerase… Expand
HLTF's Ancient HIRAN Domain Binds 3' DNA Ends to Drive Replication Fork Reversal.
- Andrew C. Kile, D. A. Chavez, +5 authors K. Cimprich
- Biology, Medicine
- Molecular cell
- 18 June 2015
Stalled replication forks are a critical problem for the cell because they can lead to complex genome rearrangements that underlie cell death and disease. Processes such as DNA damage tolerance and… Expand
The Holliday junction in an inverted repeat DNA sequence: sequence effects on the structure of four-way junctions.
- B. Eichman, J. M. Vargason, B. Mooers, P. S. Ho
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 11 April 2000
Holliday junctions are important structural intermediates in recombination, viral integration, and DNA repair. We present here the single-crystal structure of the inverted repeat sequence… Expand
Substrate-selective repair and restart of replication forks by DNA translocases.
- Rémy Bétous, Frank B Couch, A. C. Mason, B. Eichman, M. Manosas, D. Cortez
- Biology, Medicine
- Cell reports
- 27 June 2013
Stalled replication forks are sources of genetic instability. Multiple fork-remodeling enzymes are recruited to stalled forks, but how they work to promote fork restart is poorly understood. By… Expand
Domain structure of the DEMETER 5-methylcytosine DNA glycosylase
- Young Geun Mok, Rie Uzawa, +4 authors J. H. Huh
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 25 October 2010
DNA glycosylases initiate the base excision repair (BER) pathway by excising damaged, mismatched, or otherwise modified bases. Animals and plants independently evolved active BER-dependent DNA… Expand
Physical Interactions between Mcm10, DNA, and DNA Polymerase α*
- E. Warren, H. Huang, E. Fanning, W. Chazin, B. Eichman
- Materials Science, Medicine
- The Journal of Biological Chemistry
- 16 July 2009
Mcm10 is an essential eukaryotic protein required for the initiation and elongation phases of chromosomal replication. Specifically, Mcm10 is required for the association of several replication… Expand
Domain Architecture and Biochemical Characterization of Vertebrate Mcm10*
- Patrick D. Robertson, E. Warren, +7 authors B. Eichman
- Biology, Medicine
- Journal of Biological Chemistry
- 8 February 2008
Mcm10 plays a key role in initiation and elongation of eukaryotic chromosomal DNA replication. As a first step to better understand the structure and function of vertebrate Mcm10, we have determined… Expand
Structural basis for DNA binding by replication initiator Mcm10.
- E. Warren, S. Vaithiyalingam, +4 authors B. Eichman
- Biology, Medicine
- Structure
- 12 December 2008
Mcm10 is an essential eukaryotic DNA replication protein required for assembly and progression of the replication fork. The highly conserved internal domain (Mcm10-ID) has been shown to physically… Expand
Recent advances in the structural mechanisms of DNA glycosylases.
- S. Brooks, Suraj Adhikary, E. Rubinson, B. Eichman
- Biology, Medicine
- Biochimica et biophysica acta
- 2013
DNA glycosylases safeguard the genome by locating and excising a diverse array of aberrant nucleobases created from oxidation, alkylation, and deamination of DNA. Since the discovery 28years ago that… Expand