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Iron deprivation increases erythropoietin production in vitro, in normal subjects and patients with malignancy
TLDR
In clinical studies, sEPO levels rose in adult volunteers treated with DFO coupled to hydroxyethyl starch (HES‐DFO) and in patients with advanced malignancy treated with anti‐Tf receptor antibody 42/6, in a time‐ and dose‐dependent manner, indicating intracellular iron balance regulates EPO production in humans. Expand
Expression of the zinc finger gene EVI-1 in ovarian and other cancers.
TLDR
Ovarian carcinoma karyotypes showed one line with quadruplication 3(q24q27), but no other clonal structural rearrangements involving 3q26, but whole chromsome 3 and3q26 FISH performed on lines with high EVI-1 expression showed translocations involving chromosome 3q 26. Expand
Effects of all-trans retinoic acid and antireceptor antibodies on growth and programmed cell death of human myeloma cells.
TLDR
Flow cytometry rapidly detects apoptosis induced by biological agents and may be useful for in vitro screening of novel biological therapies. Expand
Phase Ia trial of murine immunoglobulin A antitransferrin receptor antibody 42/6.
TLDR
Results of a Phase Ia trial of IgA monoclonal anti-Tf receptor antibody 42/6 represent the first clinical trial of an IgA mouse mAb, and one of only a few trials in which an antibody reacting with a broad range of normal tissues has been administered. Expand
Effects of combined antigrowth factor receptor treatment on in vitro growth of multiple myeloma.
TLDR
To determine the extent to which anti-interleukin-6 (IL-6) and anti-transferrin (Tf) receptor antibodies, when used individually or combined, could limit myeloma cell growth, three cell lines were studied. Expand
Effects of transforming growth factor beta 1 on growth and apoptosis of human acute myelogenous leukemia cells.
TLDR
It is indicated that human AML cells exhibit heterogeneous growth responses to TGF-beta 1 and that some effects of TGF -beta 1 on myeloid cells occur through programmed cell death. Expand
Thymopoiesis and regulatory T cells in healthy children and adolescents
TLDR
A decrease in the thymic function with age is observed based on the fact that the level of T-cell receptor excision circles in the peripheral blood positively correlated with the proportion of regulatory T cells in healthy children and adolescents. Expand