• Publications
  • Influence
Small self-RNA generated by RNase L amplifies antiviral innate immunity
Antiviral innate immunity is initiated in response to RNA molecules that are produced in virus-infected cells. These RNAs activate signalling cascades that activate the genes that encode α- andExpand
  • 545
  • 40
An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors
We recently reported identification of a previously undescribed gammaretrovirus genome, xenotropic murine leukemia virus-related virus (XMRV), in prostate cancer tissue from patients homozygous for aExpand
  • 224
  • 31
  • PDF
Blockage of NF-kappa B signaling by selective ablation of an mRNA target by 2-5A antisense chimeras.
Activation of 2-5A-dependent ribonuclease by 5'-phosphorylated, 2',5'-linked oligoadenylates, known as 2-5A, is one pathway of interferon action. Unaided uptake into HeLa cells of 2-5A linked to anExpand
  • 218
  • 10
2-5A-dependent RNase Molecules Dimerize during Activation by 2-5A (*)
2-5A-dependent RNase is an interferon-inducible enzyme that requires 5′-phosphorylated, 2′,5′-linked oligoadenylates (2-5A) for its endoribonuclease activity against single-stranded RNAs. WeExpand
  • 237
  • 10
Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses
Significance RNase L, an antiviral enzyme activated during infection, degrades viral and cellular RNAs, inhibits protein synthesis, and restricts the replication and spread of diverse viruses. RNaseExpand
  • 99
  • 9
Basis for regulated RNA cleavage by functional analysis of RNase L and Ire1p.
RNase L and Ire1p are members of a superfamily of regulated endoribonucleases that play essential roles in mediating diverse types of cellular stress responses. 2'-5' oligoadenylates, produced inExpand
  • 100
  • 8
  • PDF
Phospholipid Scramblase 1 Potentiates the Antiviral Activity of Interferon
ABSTRACT Phospholipid scramblase 1 (PLSCR1) is an interferon (IFN)- and growth factor-inducible, calcium-binding protein that either inserts into the plasma membrane or binds DNA in the nucleusExpand
  • 88
  • 7
Integration Site Preference of Xenotropic Murine Leukemia Virus-Related Virus, a New Human Retrovirus Associated with Prostate Cancer
ABSTRACT Xenotropic murine leukemia virus-related virus (XMRV) is a new human gammaretrovirus identified in prostate cancer tissue from patients homozygous for a reduced-activity variant of theExpand
  • 115
  • 7
  • PDF
A Bipartite Model of 2-5A-dependent RNase L*
The 2-5A-dependent RNase (RNase L) is a tightly regulated endoribonuclease of higher vertebrates that is catalytically active only after engaging unusual effector molecules consisting of theExpand
  • 106
  • 6
  • PDF
The intracisternal A-particle proximal enhancer-binding protein activates transcription and is identical to the RNA- and DNA-binding protein p54nrb/NonO.
The long terminal repeats of murine intracisternal A particles (IAPs) contain an IAP proximal enhancer (IPE) element that is inactive in murine F9 embryonal carcinoma cells and active in the parietalExpand
  • 81
  • 5