• Publications
  • Influence
Innate Immune and Chemically Triggered Oxidative Stress Modifies Translational Fidelity
Translational fidelity, essential for protein and cell function, requires accurate transfer RNA (tRNA) aminoacylation. Purified aminoacyl-tRNA synthetases exhibit a fidelity of one error per 10,000Expand
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Nuclear translation visualized by ribosome-bound nascent chain puromycylation
A new method for visualizing translation in cells via standard immunofluorescence microscopy provides evidence for translation in the nucleoplasm and nucleolus.
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Dendritic Cells Cross-Dressed with Peptide MHC Class I Complexes Prime CD8+ T Cells1
The activation of naive CD8+ T cells has been attributed to two mechanisms: cross-priming and direct priming. Cross-priming and direct priming differ in the source of Ag and in the cell that presentsExpand
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Nurse practitioner practice and deployment: electronic mail Delphi study.
BACKGROUND The nature of modern government and needs of policy-makers demand accurate information that is delivered quickly. This study was part of a larger project for the Department of HealthExpand
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Unexpected Role for the Immunoproteasome Subunit LMP2 in Antiviral Humoral and Innate Immune Responses
Proteasomes are multisubunit proteases that initiate degradation of many Ags presented by MHC class I molecules. Vertebrates express alternate forms of each of the three catalytic proteasomeExpand
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Distinct Pathways Generate Peptides from Defective Ribosomal Products for CD8+ T Cell Immunosurveillance
To understand better the endogenous sources of MHC class I peptide ligands, we generated an antigenic reporter protein whose degradation is rapidly and reversibly controlled with Shield-1, aExpand
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Translating DRiPs: progress in understanding viral and cellular sources of MHC class I peptide ligands
It has been 15 years since we proposed the defective ribosomal product (DRiP) hypothesis to explain the rapid presentation of viral peptides by MHC class I molecules on the surface of infected cells.Expand
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Beyond mice and men: environmental change, immunity and infections in wild ungulates
In the face of rapid environmental change, anticipating shifts in microparasite and macroparasite dynamics, including emergence events, is an enormous challenge. We argue that immunological studiesExpand
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Innate and adaptive immune responses in migrating spring-run adult chinook salmon, Oncorhynchus tshawytscha.
Adult Chinook salmon (Oncorhynchus tshawytscha) migrate from salt water to freshwater streams to spawn. Immune responses in migrating adult salmon are thought to diminish in the run up to spawning,Expand
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Degrees of choice.
  • B. Dolan
  • Medicine
  • Emergency nurse : the journal of the RCN Accident…
  • 1 June 2001
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