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A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila
Forward genetic screens in model organisms have provided important insights into numerous aspects of development, physiology and pathology. With the availability of complete genome sequences and theExpand
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Molecular, Anatomical, and Functional Organization of the Drosophila Olfactory System
BACKGROUND Olfactory receptor neurons (ORNs) convey chemical information into the brain, producing internal representations of odors detected in the periphery. A comprehensive understanding of theExpand
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Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics.
During development of the adult Drosophila visual system, axons of the eight photoreceptors in each ommatidium fasciculate together and project as a single bundle towards the optic lobes of theExpand
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A single class of olfactory neurons mediates behavioural responses to a Drosophila sex pheromone
Insects, like many other animals, use sex pheromones to coordinate their reproductive behaviours. Volatile pheromones are detected by odorant receptors expressed in olfactory receptor neurons (ORNs).Expand
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Dispatched, a Novel Sterol-Sensing Domain Protein Dedicated to the Release of Cholesterol-Modified Hedgehog from Signaling Cells
Members of the Hedgehog (Hh) family of secreted signaling proteins function as potent short-range organizers in animal development. Their range of action is limited by a C-terminal cholesterol tetherExpand
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Genetic Analysis of Netrin Genes in Drosophila: Netrins Guide CNS Commissural Axons and Peripheral Motor Axons
Two tandem Netrin genes in Drosophila are expressed at the midline of the developing CNS and in different subsets of neurons, muscles, and epidermal patches. In embryos carrying a small deficiencyExpand
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A receptor that mediates the post-mating switch in Drosophila reproductive behaviour
Mating in many species induces a dramatic switch in female reproductive behaviour. In most insects, this switch is triggered by factors present in the male’s seminal fluid. How these factors exertExpand
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Genome-scale functional characterization of Drosophila developmental enhancers in vivo
Transcriptional enhancers are crucial regulators of gene expression and animal development and the characterization of their genomic organization, spatiotemporal activities and sequence properties isExpand
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Rac function and regulation during Drosophila development
Rac GTPases regulate the actin cytoskeleton to control changes in cell shape. To date, the analysis of Rac function during development has relied heavily on the use of dominant mutant isoforms. Here,Expand
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Trio Combines with Dock to Regulate Pak Activity during Photoreceptor Axon Pathfinding in Drosophila
Correct pathfinding by Drosophila photoreceptor axons requires recruitment of p21-activated kinase (Pak) to the membrane by the SH2-SH3 adaptor Dock. Here, we identify the guanine nucleotide exchangeExpand
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