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The gut microbiota influences blood-brain barrier permeability in mice
The intestinal microbiota helps to maintain the integrity of the blood-brain barrier in fetal and adult mice. The Gut Microbiota and the Blood-Brain Barrier The blood-brain barrier is an importantExpand
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A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus
In systemic lupus erythematosus, antibodies against double-stranded DNA are a major contributor to renal disease. We have previously demonstrated that the pentapeptide Asp/Glu-Trp-Asp/Glu-Tyr-Ser/GlyExpand
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Autoimmune diseases
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Combined oral contraceptives in women with systemic lupus erythematosus.
BACKGROUND Oral contraceptives are rarely prescribed for women with systemic lupus erythematosus, because of concern about potential negative side effects. In this double-blind, randomized,Expand
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Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice
Dendritic cells (DCs) that orchestrate mucosal immunity have been studied in mice. Here we characterized human gut DC populations and defined their relationship to previously studied human and mouseExpand
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Selective dysregulation of the FcγIIB receptor on memory B cells in SLE
The inappropriate expansion and activation of autoreactive memory B cells and plasmablasts contributes to loss of self-tolerance in systemic lupus erythematosus (SLE). Defects in the inhibitory FcExpand
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Estrogen alters thresholds for B cell apoptosis and activation.
Estrogen is thought to contribute to the increased frequency of autoimmune disorders occurring in females, but a molecular basis for its effects on autoimmunity remains to be elucidated. We haveExpand
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Cognition and immunity; antibody impairs memory.
Patients with lupus (SLE) experience progressive cognitive loss without evidence of CNS vascular disease or inflammation. SLE patients produce anti-DNA antibodies that crossreact with NMDA receptorsExpand
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Human lupus autoantibodies against NMDA receptors mediate cognitive impairment
Neuropsychiatric systemic lupus erythematosus, which often entails cognitive disturbances and memory loss, has become a major complication for lupus patients. Previously, we developed a murine modelExpand
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Losing your nerves? Maybe it's the antibodies
We propose that the normal immunocompetent B cell repertoire is replete with B cells making antibodies that recognize brain antigens. Although B cells that are reactive with self antigen are normallyExpand
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