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Do Benzodiazepines Still Deserve a Major Role in The Treatment of Psychiatric Disorders? A Critical Reappraisal
TLDR
A critical appraisal of the current use and role of BZDs in psychiatric disorders and their disadvantages is provided, with specific emphasis on anxiety and affective disorders, sleep disorders, alcohol withdrawal, violent and aggressive behaviours in psychoses, and neuroleptic-induced disorders. Expand
Romantic Attachment in Patients with Mood and Anxiety Disorders
TLDR
The findings indicate that patients with different psychiatric disorders would be characterized by higher scores on both the ECR anxiety and the avoidance scales, as well as by the preoccupied style of attachment. Expand
Cytokine Polymorphisms in the Pathophysiology of Mood Disorders
TLDR
The data support the existence of a genetic profile related to pro-inflammatory cytokines in patients affected by mood disorders and suggest the presence of different pathogenetic mechanisms involved in the susceptibility of phenotypically different mood disorders. Expand
Selective DNA Methylation of BDNF Promoter in Bipolar Disorder: Differences Among Patients with BDI and BDII
TLDR
Findings suggest selective changes in DNA methylation of BDNF promoter in subjects with BD type II and highlight the importance of epigenetic factors in mediating the onset and/or susceptibility to BD, providing new insight into the mechanisms of gene expression. Expand
Duration of untreated illness and suicide in bipolar disorder: a naturalistic study
TLDR
Results indicate a potential association between a longer DUI and a worse outcome in BD, particularly in terms of suicidality, and confirm the clinical relevance of early diagnosis and pharmacological intervention with mood stabilizers in BD. Expand
How to manage obsessive-compulsive disorder (OCD) under COVID-19: A clinician's guide from the International College of Obsessive Compulsive Spectrum Disorders (ICOCS) and the Obsessive-Compulsive
TLDR
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Expand
The C9ORF72 hexanucleotide repeat expansion is a rare cause of schizophrenia
TLDR
The frequency of the C9ORF72 hexanucleotide repeat expansions in a population of 298 patients with schizophrenia or schizoaffective disorder was determined and the pathogenic repeat expansion was detected in 2 patients. Expand
Epidemiologic and clinical updates on impulse control disorders: a critical review
TLDR
The article summarizes the phenomenology, epidemiology and comorbidity of the ICDs and particular attention is paid to the relationship between I CDs and obsessive–compulsive disorder (OCD). Expand
Validation of the Italian version of the "Mood Disorder Questionnaire" for the screening of bipolar disorders
TLDR
The results seem to indicate a good accuracy of MDQ, and confirm the results of recent surveys conducted in the USA, but the instrument needs to be validated in other settings (e.g. in general practice). Expand
Serotonin-norepinephrine reuptake inhibitors in the treatment of obsessive-compulsive disorder: A critical review.
TLDR
The SNRIs may represent a valid alternative to the SSRIs, particularly in specific cases, and might be preferred for patients with certain types of treatment-resistant OCD or those with particular comorbid conditions. Expand
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