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Classification and basic pathology of Alzheimer disease
The lesions of Alzheimer disease include accumulation of proteins, losses of neurons and synapses, and alterations related to reactive processes. Extracellular Aβ accumulation occurs in theExpand
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Alzheimer disease models and human neuropathology: similarities and differences
Animal models aim to replicate the symptoms, the lesions or the cause(s) of Alzheimer disease. Numerous mouse transgenic lines have now succeeded in partially reproducing its lesions: theExpand
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Specific targeting of the GABA-A receptor α5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice
An imbalance between inhibitory and excitatory neurotransmission has been proposed to contribute to altered brain function in individuals with Down syndrome (DS). Gamma-aminobutyric acid (GABA) isExpand
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Projections from the parahippocampal region to the prefrontal cortex in the rat: evidence of multiple pathways
The purpose of the present study was to investigate, by means of anterograde tracing methods, the detailed organization of the parahippocampal–prefrontal projections in the rat brain. Efferents fromExpand
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Prelimbic cortex specific lesions disrupt delayed-variable response tasks in the rat.
The role of the prelimbic cortex (PL) in rats was investigated with excitotoxic lesions. PL lesions altered the alternation scores in spontaneous and reinforced spatial delayed-alternation tasks. PLExpand
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Age-related evolution of amyloid burden, iron load, and MR relaxation times in a transgenic mouse model of Alzheimer's disease
T1 and T2 magnetic resonance relaxation times have the potential to provide biomarkers of amyloid-beta deposition that could be helpful to the development of new therapies for Alzheimer's disease.Expand
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In vivo MRI and histological evaluation of brain atrophy in APP/PS1 transgenic mice
Regional cerebral atrophy was evaluated in APP/PS1 mice harboring mutated transgenes linked to familial Alzheimer's disease, using complementary methods. In vivo high resolution MRI was selected forExpand
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Altered emotional and motivational processing in the transgenic rat model for Huntington’s disease
Huntington disease (HD) is caused by an expansion of CAG repeat in the Huntingtin gene. Patients demonstrate a triad of motor, cognitive and psychiatric symptoms. A transgenic rat model (tgHD rats)Expand
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Detection of vascular alterations by in vivo magnetic resonance angiography and histology in APP/PS1 mouse model of Alzheimer’s disease
ObjectThe brain of patients with Alzheimer’s disease (AD) is characterized by the presence of amyloid plaques and neurofibrillary tangles. Vascular alterations such as amyloid angiopathy are alsoExpand
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Functional dissociation between dorsal and ventral regions of the medial prefrontal cortex in rats
In order to investigate the respective roles of dorsal and ventral parts of the medial prefrontal cortex (mPFC) on a delayed alternation task, the acquisition of which is disrupted by large mPFCExpand
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