• Publications
  • Influence
Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein.
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Role of the CXCL8-CXCR1/2 Axis in Cancer and Inflammatory Diseases
The chemokine receptors CXCR1/2 and their ligand CXCL8 are essential for the activation and trafficking of inflammatory mediators as well as tumor progression and metastasis. The CXCL8-CXCR1/2Expand
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Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment
Protein disulfide isomerase (PDI), an endoplasmic reticulum chaperone protein, catalyzes disulfide bond breakage, formation, and rearrangement. The effect of PDI inhibition on ovarian cancerExpand
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Small Molecule Inhibitors of CXCR4
CXCR4 is a G-protein-coupled receptor involved in a number of physiological processes in the hematopoietic and immune systems. The SDF-1/CXCR4 axis is significantly associated with several diseases,Expand
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Role of the CXCL 8-CXCR 1 / 2 Axis in Cancer and Inflammatory Diseases
The chemokine receptors CXCR1/2 and their ligand CXCL8 are essential for the activation and trafficking of inflammatory mediators as well as tumor progression and metastasis. The CXCL8-CXCR1/2Expand
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Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy.
Aldehyde dehydrogenase (ALDH) activity is commonly used as a marker to identify cancer stem-like cells. The three ALDH1A isoforms have all been individually implicated in cancer stem-like cells andExpand
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Enhanced regression of tumors in mice with combined chemotherapy and immunotherapy
Objective: The main aim of the present study is to assess the therapeutic efficacy of whole cell vaccines and tumor extracts with or without combination chemotherapy using the cytotoxic compound, aExpand
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Are we living in the end of the blockbuster drug era?
For the last two decades, we have seen remarkable growth in the pharmaceutical industry. This growth has mainly been due to the approximately 100 new blockbuster drugs, such as Lipitor®Expand
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– N , N ́ – Disubstituted – 2 – ( Substituted Benzenesulphonyl ) – Glutamamides as Antitumor Agents . Part 2 . Synthesis , Biological Activity and QSAR Study
Bikash Debnath, Kolluru Srikanth, Suchandra Banarjee, and Tarun Jha 1 Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700Expand
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