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Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies
Antibodies capable of neutralizing HIV-1 often target variable regions 1 and 2 (V1V2) of the HIV-1 envelope, but the mechanism of their elicitation has been unclear. Here we define the developmentalExpand
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In-depth determination and analysis of the human paired heavy- and light-chain antibody repertoire
High-throughput immune repertoire sequencing has emerged as a critical step in the understanding of adaptive responses following infection or vaccination or in autoimmunity. However, determination ofExpand
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Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoires
Significance We applied a very recently developed experimental strategy for high-throughput sequencing of paired antibody heavy and light chains along with large-scale computational structuralExpand
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High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire
Each B-cell receptor consists of a pair of heavy and light chains. High-throughput sequencing can identify large numbers of heavy- and light-chain variable regions (VH and VL) in a given B-cellExpand
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Identification and characterization of the constituent human serum antibodies elicited by vaccination
Significance Most vaccines confer immunity by eliciting long-term production of antibodies that bind to and neutralize the vaccine antigen. Remarkably, very little is known regarding the identities,Expand
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Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires
The design of immunogens that elicit broadly reactive neutralizing antibodies (bnAbs) has been a major obstacle to HIV-1 vaccine development. One approach to assess potential immunogens is to useExpand
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Low CD21 expression defines a population of recent germinal center graduates primed for plasma cell differentiation
A distinct population of B cells that respond to vaccination serve as potential plasma cell precursors. Plasma cell precursors Memory B cells are critical players in the rapid secondary immuneExpand
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Glycan Masking Focuses Immune Responses to the HIV‐1 CD4‐Binding Site and Enhances Elicitation of VRC01‐Class Precursor Antibodies
SUMMARY An important class of HIV‐1 broadly neutralizing antibodies, termed the VRC01 class, targets the conserved CD4‐binding site (CD4bs) of the envelope glycoprotein (Env). An engineered Env outerExpand
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Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination
Molecular understanding of serological immunity to influenza has been confounded by the complexity of the polyclonal antibody response in humans. Here we used high-resolution proteomics analysis ofExpand
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Hierarchically designed agarose and poly(ethylene glycol) interpenetrating network hydrogels for cartilage tissue engineering.
A new method for encapsulating cells in interpenetrating network (IPN) hydrogels of superior mechanical integrity was developed. In this study, two biocompatible materials-agarose and poly(ethyleneExpand
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