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A prospective natural-history study of coronary atherosclerosis.
TLDR
In patients who presented with an acute coronary syndrome and underwent percutaneous coronary intervention, major adverse cardiovascular events occurring during follow-up were equally attributable to recurrence at the site of culprit lesions and to nonculprit lesions. Expand
Measurement of fractional flow reserve to assess the functional severity of coronary-artery stenoses.
TLDR
In patients with coronary stenosis of moderate severity, FFR appears to be a useful index of the functional severity of the stenoses and the need for coronary revascularization. Expand
Percutaneous coronary intervention of functionally nonsignificant stenosis: 5-year follow-up of the DEFER Study.
TLDR
Five-year outcome after deferral of PCI of an intermediate coronary stenosis based on FFR >/=0.75 is excellent and the risk of cardiac death or myocardial infarction related to this stenosis is <1% per year and not decreased by stenting. Expand
Experimental Basis of Determining Maximum Coronary, Myocardial, and Collateral Blood Flow by Pressure Measurements for Assessing Functional Stenosis Severity Before and After Percutaneous
TLDR
These results provide the experimental basis for determining relative maximum flow or fractional flow reserve of both the epicardial coronary artery and the myocardium, including collateral flow, from pressure measurements during maximum arteriolar vasodilation. Expand
Fractional flow reserve versus angiography for guiding percutaneous coronary intervention.
TLDR
Routine measurement of FFR in patients with multivessel coronary artery disease who are undergoing PCI with drug-eluting stents significantly reduces the rate of the composite end point of death, nonfatal myocardial infarction, and repeat revascularization at 1 year. Expand
Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease.
TLDR
In patients with stable coronary artery disease and functionally significant stenoses, FFR-guided PCI plus the best available medical therapy, as compared with the best Available medical therapy alone, decreased the need for urgent revascularization. Expand
Diagnostic performance of noninvasive fractional flow reserve derived from coronary computed tomography angiography in suspected coronary artery disease: the NXT trial (Analysis of Coronary Blood
TLDR
FFR(CT) provides high diagnostic accuracy and discrimination for the diagnosis of hemodynamically significant CAD with invasive FFR as the reference standard when compared with anatomic testing by using coronary CTA, which led to a marked increase in specificity. Expand
Fractional flow reserve versus angiography for guiding percutaneous coronary intervention in patients with multivessel coronary artery disease: 2-year follow-up of the FAME (Fractional Flow Reserve
TLDR
Routine measurement of FFR in patients with multivessel CAD undergoing PCI with drug-eluting stents significantly reduces mortality and myocardial infarction at 2 years when compared with standard angiography-guided PCI. Expand
Intracoronary Injection of CD133-Positive Enriched Bone Marrow Progenitor Cells Promotes Cardiac Recovery After Recent Myocardial Infarction: Feasibility and Safety
TLDR
In patients with recent myocardial infarction, intracoronary administration of enriched CD133+ cells is feasible but was associated with increased incidence of coronary events, Nevertheless, it seems to be associated with improved left ventricular performance paralleled with increasedMyocardial perfusion and viability. Expand
Fractional flow reserve-guided PCI for stable coronary artery disease.
TLDR
In patients with stable coronary artery disease, FFR-guided PCI, as compared with medical therapy alone, improved the outcome and was significantly lower in the PCI group than in the medical-therapy group. Expand
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