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Cartilage MRI T2 relaxation time mapping: overview and applications.
In vivo cartilage T2 mapping can improve understanding of arthritis, cartilage aging, and response of cartilage to exercise and help to develop new pharmaceuticals and surgical techniques for preserving cartilage.
Correlation of white matter diffusivity and anisotropy with age during childhood and adolescence: a cross-sectional diffusion-tensor MR imaging study.
Diffusion-tensor MR imaging results indicate that white matter maturation assessed at different ages involves increases in both white matter density and organization during childhood and adolescence.
Developmental differences in white matter architecture between boys and girls
Sex differences in the development of white matter microstructure were investigated in a cohort of normal children ages 5–18 in a DTI study, indicating differing developmental trajectories in white matter for boys and girls and the importance of taking sex into account in developmental DTI studies.
Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy.
It is suggested that ischemia-hypoxia is a powerful stimulus for spontaneous coagulation leading to reperfusion deficits and autophagic/lysosomal cell death in brain.
Cognitive functions correlate with white matter architecture in a normal pediatric population: A diffusion tensor MRI study
The results of DTI are consistent with the hypothesis that regionally specific increased fiber organization is a mechanism responsible for the normal development of white matter tracts.
Measures of molecular composition and structure in osteoarthritis.
MR imaging and T2 mapping of femoral cartilage: in vivo determination of the magic angle effect.
- T. Mosher, H. Smith, B. Dardzinski, V. Schmithorst, M. B. Smith
- Biology, MedicineAJR. American journal of roentgenology
- 1 September 2001
The effect of orientation on cartilage T2 is substantially less than that predicted from prior ex vivo studies, and it is unlikely that the "magic angle effect" accounts for regional differences in cartilage signal intensity observed in clinical imaging.
The application of porous‐media theory to the investigation of time‐dependent diffusion in in vivo systems
Based on D(t) maps generated from RIF‐1 tumors, T appears to be much more sensitive than S/V in differentiating between necrotic and non‐necrotic tissue, and should therefore provide a useful tool for monitoring the progress of therapeutic interventions.
Anterior and posterior cruciate ligaments at different patient ages: MR imaging findings.
During growth, angulation of the ACL is age dependent and the angle and morphologic changes of the PCL are age dependent throughout skeletal maturation.
Spatial variation of T2 in human articular cartilage.
There is a reproducible pattern of increasing T2 that is proportional to the known spatial variation in cartilage water and is inversely proportionalto the distribution of proteoglycans, and the authors postulate that these regional T2 differences are secondary to the restricted mobility of Cartilage water within an anisotropic solid matrix.